Evidence map›Paper›PMID 41332304›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact.

Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Huifen ZhouSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang, 310053, P. R. China.
Yingying ZhangSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang, 310053, P. R. China.
Peng ZhouSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang, 310053, P. R. China.
Haofang WanAcademy of Chinese Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang, 310053, P. R. China.
Lingling LiState Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Human Phenome Institute, Fudan University, No. 220 Handan Road, Shanghai, 200433, P. R. China.
Bin XuDepartment of Neurology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No.318 owang Road, Hangzhou, Zhejiang, 310000, P. R. China.
Yuping WanDepartment of Acupuncture, Jingzhou Hospital of Traditional Chinese Medicine, No.172, East Jiangjin Road, Jingzhou, Hubei, 434000, P. R. China.
Yingming SongDepartment of Encephalopathy, Luohe Hospital of Traditional Chinese Medicine, No.649, South Traffic Road, Luohe, Henan, 462000, P. R. China.
Yi KangDepartment of Encephalopathy, Jiulongpo District Hospital of Traditional Chinese Medicine, No.160, Longquan Village, Chongqing City, 400080, P. R. China.
Hongbo ZhangInstitute of Life and Health, Huzhou College, No.1, Bachelor Road, Huzhou, Zhejiang, 313000, P. R. China.
Min ShiPharmacy department, The Affiliated Rehabilitation Hospital of Zhejiang Chinese Medical University, 2828, Binsheng Road, Hangzhou, Zhejiang, 310000, P. R. China.
Qun HouDepartment of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No.54, Post and Telecommunications Road, Hangzhou, Zhejiang, 310000, P. R. China.
Jiehong YangSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang, 310053, P. R. China.
Chen DingState Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Human Phenome Institute, Fudan University, No. 220 Handan Road, Shanghai, 200433, P. R. China.
Wei FuDepartment of Cardiac-Cerebral Diseases, Yinchuan Cardiac-Cerebral Treatment Internet Hospital, No. 6 Ning'an East Lane, Yinchuan, Ningxia, 750011, P. R. China.
Buchang ZhaoBuchang Pharmaceutical Co., Ltd., No. 16 Buchang Road, Xi'an, Shaanxi, 712046, P. R. China.
Haitong WanSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang, 310053, P. R. China.ORCID https://orcid.org/0000-0001-5726-7214

Funding

National Natural Science Foundation of China 82174066National Natural Science Foundation of China 82330120Natural Science Foundation of Zhejiang Province LY23H280007Natural Science Foundation of Zhejiang Province LZ23H270002Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0528100,2024ZD0528102
6 · The paper itself

Abstract

Ischemic stroke (IS) initiates complex systemic responses that extend beyond focal brain injury. To capture these multifaceted changes, proteomics, untargeted metabolomics, and lipidomics are integrated from IS patients spanning a range of clinical severities. This multi-omics approach reveals distinct molecular subtypes characterized by immune activation, oxidative stress, and metabolic dysregulation. Notably, elevated levels of migrasomes are identified in patient plasma and mouse brain tissue. Proteomic profiling of these migrasomes shows enrichment in complement, coagulation, and cholesterol-associated pathways. Functional assays further demonstrate that migrasomes derived from peripheral immune cells exacerbate ischemic injury and intensify post-stroke inflammation. Together, these findings position migrasomes as critical drivers of IS pathophysiology and highlight them as promising targets for therapeutic intervention.

Indexed as

Brain IschemiaIschemic StrokeAnimalsBrainHumansMetabolomicsMiceOxidative StressProteomicsischemic strokemigrasomesproteomicsuntargeted lipidomicsuntargeted metabolomics

Identifiers

PMID41332304
PMCPMC12866748

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.