Evidence map›Paper›PMID 41332294›Full record

ArticleVeterinary ophthalmology2026

Topical Omidenepag Isopropyl Lowers Intraocular Pressure in Normal and Glaucomatous Cats: A Pilot Study.

Kazuya Oikawa, Julie A Kiland, Hayden G Zaluckyj, Anjali Rai, Virginia Mathu, Gillian J McLellan

Abstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kazuya OikawaSurgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-2202-4786
Julie A KilandOphthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-9019-2346
Hayden G ZaluckyjSurgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Anjali RaiSurgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Virginia MathuSurgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Gillian J McLellanSurgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-6505-7476

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
Vision Research Training ProgramT32EY027721 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2018 to 2026
$1.5M
Short-Term Research Training of Veterinary Students in WisconsinT35OD011078 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI BJORLING, DALE EDMOND, JORGENSEN, JOAN S · 2012 to 2025
$1.0M
The role of LTBP2 in glaucomaR21EY034373 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI MCLELLAN, GILLIAN JANE · 2023 to 2024
$428k
ACVO Vision for Animals Foundation VAF2025-3NEI NIH HHS P30 EY016665NEI NIH HHS R21 EY034373NEI NIH HHS T32 EY027721NIH HHS P30 EY016665NIH HHS T32 EY027721NIH HHS T35 OD011078Research to Prevent Blindness
6 · The paper itself

Abstract

purposeTo evaluate the effects of topical prostaglandin E2 receptor 2 (EP2) agonist, omidenepag isopropyl (OMDI), on intraocular pressure (IOP) and pupil diameter (PD) in normal cats and cats with feline congenital glaucoma (FCG). ANIMALS STUDIED: Ten FCG cats and 8 normal cats.

methodsIn this prospective, randomized, placebo-controlled, masked pilot study, normal and FCG cats received one drop of 0.002% OMDI ophthalmic solution in one eye and artificial tears in the contralateral eye. IOP and PD were measured by a masked observer at baseline and at multiple time points up to 32-36 h post-administration.

resultsTopical 0.002% OMDI significantly lowered IOP compared to controls in both normal and FCG cats. In normal cats, the effect was significant up to 12 h after instillation, with a maximal reduction from baseline of 7.3 mmHg (43.5%). In FCG cats, the effect was significant from 2 to 8 h after instillation, with a maximal reduction from baseline of 16.7 mmHg (60.2%). No significant effect on pupil diameter or signs of ocular irritation was observed in either group.

conclusionsA single topical drop of 0.002% OMDI significantly lowers IOP in normal and FCG cats without inducing miosis. Our findings support that topical selective EP2 agonists may be a promising therapeutic option for feline glaucoma and provide information relevant to dosing intervals for future studies.

Indexed as

Cat DiseasesGlaucomaIntraocular PressurePyridinesAdministration, TopicalAnimalsCatsFemaleGlycineMaleOphthalmic SolutionsPilot ProjectsProspective StudiesPyrazolesGlycineomidenepag isopropylOphthalmic SolutionsPyrazolesPyridinescatsEP2 agonistglaucomaintraocular pressureOmidenepag isopropyl

Identifiers

PMID41332294
PMCPMC12795517

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.