ArticleTransplantation2026
The Impact of Recipient HIV Status on Kidney Transplant Outcomes in the United Kingdom: Have Previous Studies Overestimated Risk?
Article in Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Donor-derived viral infections: the usual suspects and the new kids on the block.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite increasing literature on kidney transplantation in people with HIV, studies have largely overlooked the confounding impact of ethnicity and socioeconomic deprivation. This study aimed to assess posttransplant outcomes in HIV-positive recipients, adjusting for these key factors.
methodsPopulation-cohort study of single kidney-alone transplants (2005-2022) using the UK Transplant Registry. The primary outcome was graft survival. Multivariable regression models evaluated the impact of recipient HIV status on transplant outcomes.
resultsWe included 30 013 recipients: 20 517 deceased-donor (200 HIV-positive recipients) and 9496 live-donor (44 HIV-positive recipients). Multivariable models revealed no significant differences in 5-y graft survival for HIV-positive versus negative recipients, in either deceased (adjusted hazard ratio = 0.93, 95% confidence interval 0.61-1.41, P = 0.721) or live donor cohorts (adjusted hazard ratio = 1.02 [0.31-3.33]; P = 0.973). Recipient HIV status was also not associated with patient survival or delayed graft function in either cohort. HIV-positive recipients were more likely to experience acute rejection within 12 mo (deceased adjusted odds ratio = 1.53 [0.94-2.50]; P = 0.091 and live adjusted odds ratio = 3.43 [1.44-8.19]; P = 0.006) and had marginally lower adjusted 12-mo estimated glomerular filtration rate. Crude 12-mo acute rejection rates for HIV-positive versus negative recipients were 24.8% versus 14.2% (deceased) and 37.5% versus 15.3% (live). For all posttransplant outcomes, removing adjustment for ethnicity and deprivation led to greater adjusted risk estimates for HIV-positive recipients.
conclusionsHIV-positive recipients achieve excellent graft and patient survival, which are no different from HIV-negative recipients on adjusted analyses. Previous studies without ethnicity or socioeconomic-deprivation adjustment have likely overestimated the risks of recipient HIV-positive transplants. HIV-positive recipients with an indication for kidney transplantation should have equitable access to assessment, listing and offers for kidney transplantation.
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