ArticleJournal of periodontal & implant science2026
Bone regenerative therapy using molded collagenated equine bone mineral with rhBMP-2 in a canine peri-implantitis model: a proof of concept.
Article in Journal of periodontal & implant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to establish a proof of concept for the guided bone regeneration (GBR) procedure using molded collagenated equine bone mineral (CEBM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) in a canine peri-implantitis model, and to identify the key factors essential for effective bone regeneration in peri-implant defects.
methodsTwelve dental implants were placed in the mandibles of 4 adult male beagle dogs. Each implant was randomly assigned to 1 of 3 groups: GBR with molded CEBM soaked in rhBMP-2 solution (CEBM/BMP2 group, n=4); GBR with molded CEBM alone (CEBM group, n=4); or open flap debridement (OFD group, n=4). Peri-implantitis was induced using cotton retraction cords following osseointegration. After ligature removal, all groups underwent OFD with implant surface decontamination, and GBR was subsequently performed according to group allocation. No further treatment was provided in the OFD group. Clinical and radiographic evaluations were conducted at 4-week intervals, and at 16 weeks, histological, fluorescent labeling, and micro-computed tomographic (micro-CT) analyses were performed.
resultsThe CEBM/BMP2 group demonstrated a significantly higher bone volume fraction in micro-CT analysis, alongside superior histomorphometric outcomes, including greater first bone-to-implant contact height, crestal height, and new bone area. The mean re-osseointegration ratio was notably higher in the CEBM/BMP2 group (buccal: 74%, lingual: 94%) compared to both the CEBM (buccal: 20%, lingual: 35%) and OFD groups (buccal: 12%, lingual: 45%).
conclusionsThe GBR procedure using molded CEBM with rhBMP-2 substantially enhanced new bone formation and implant re-osseointegration in peri-implantitis-associated defects, compared to molded CEBM alone or OFD without GBR.
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