Trial reportZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2025
[Performance evaluation of different filtration fractions during daytime continuous renal replacement therapy].
Trial report in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectivesTo investigate the effects of different filtration fractions (FFs) during continuous venovenous hemodiafiltration (CVVHDF) post-dilution.
methodsThis study employed a single-blind, head-to-head randomized controlled design. Patients who underwent daytime continuous renal replacement therapy (CRRT) in the Department of Nephrology, the Second Affiliated Hospital of Nanchang University between April 2022 and June 2023 were prospectively enrolled. They were randomly assigned to either a low FF group (FF set at 20%-<25%) or a high FF group (FF set at 25%-30%). All patients received post-dilution CVVHDF with systemic heparin anticoagulation. The primary outcome was extracorporeal circuit coagulation, comprehensively assessed through dynamic monitoring of arterial pressure, venous pressure, and transmembrane pressure, combined with filter clotting grading at the end of the session. Secondary outcomes included changes in serum creatinine, urea, potassium, and pH levels before and after treatment to evaluate efficacy.
resultsA total of 40 patients were included in both the low FF group and the high FF group. The baseline characteristics showed no statistically significant differences between the two groups (all
conclusionsFor patients with a relatively short treatment duration of 10-12 h undergoing post-dilution CVVHDF, employing an FF of 25%-30% does not pose a higher risk of extracorporeal circuit coagulation compared to an FF of 20%-<25%, but shows higher creatinine clearance.
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