ReviewJournal of veterinary science2025
Canine and feline mesenchymal stem cells: an integrative review of direct comparative studies by species and tissue source.
Review in Journal of veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Promises and Perspectives of Mesenchymal Stromal Cells in Companion and Farm Animals.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
importanceMesenchymal stem cells (MSCs) play a pivotal role in advancing veterinary regenerative medicine in dogs and cats and serve as valuable preclinical models for human therapies. Despite their widespread application, fundamental knowledge gaps and the absence of standardized criteria for canine and feline MSCs remain. This review focuses exclusively on direct comparative studies across species and tissue sources to support evidence-based practices in which clinical use often precedes full scientific validation. OBSERVATIONS: This review consolidates available comparative studies of canine and feline MSCs, categorizing them by species, tissue origin, and donor factors. We systematically assessed fundamental biological properties of MSCs (yield, morphology, proliferation, differentiation) and functionalities (immunomodulation, angiogenesis, migration). Overall, MSCs from both species exhibit properties comparable to those of human MSCs. However, canine MSCs have been more extensively studied across diverse tissues, whereas feline MSC research remains primarily restricted to adipose tissue and bone marrow. Notable interspecies and tissue-specific differences include proliferation rate, chondrogenic potential, and surface marker variability. Donor factors such as age also influence MSC behavior. Nevertheless, inconsistencies in sampling sites, culture protocols, and surface marker panels across studies continue to pose challenges for achieving a comprehensive understanding through direct comparison. CONCLUSIONS AND RELEVANCE: Establishing consistent characteristics of MSCs in companion animals requires well-designed and controlled comparative studies. Standardization of MSC characterization, production, and application has been widely advocated. This review highlights ongoing efforts to address species- and tissue-specific knowledge gaps and emphasizes the need for additional comparative research to strengthen the preclinical and therapeutic utility of MSCs, thereby advancing evidence-based stem cell therapies in veterinary medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.