SynthesisAIDS research and therapy2025
Viral load suppression after enhanced adherence counseling among HIV patients on antiretroviral therapy (2019-2024): a systematic review and meta-analysis in East Africa.
Synthesis in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionViral load suppression is essential for reducing human immunodeficiency virus (HIV) related morbidity and mortality. To eliminate the HIV epidemic and enhance adherence to antiretroviral therapy (ART) globally, the Joint United Nations Program on HIV/AIDS and the World Health Organization (WHO) recommend enhanced adherence counseling (EAC) for individuals with a viral load above 1000 copies/ml. EAC helps identify and address adherence barriers, assisting patients in recognizing challenges and developing an effective plan to achieve viral load suppression. It also enables early detection of ART failure, ensuring a timely and appropriate switch to second-line medications.
methodWe conducted a systematic review and meta-analysis by performing comprehensive literature search in PubMed, Google Scholar, Hinari-Research4life, and Since Direct to identify relevant articles. Data were extracted via an Excel spreadsheet (version 5.1) and then imported into STATA (version 17.1) for analysis. A random-effects model was applied to the pooled effect of the outcomes, with a 95% confidence interval, which was visualized using a forest plot. Heterogeneity was assessed via I
resultsThis systematic review and meta-analysis included eleven primary studies with a total of 4488 participants. The pooled rate of viral load suppression after enhance adherence counseling among HIV patients on ART was 63% [95%CI: ( 55-71)], with significant heterogeneity (I
conclusionThe rate of viral load suppression following enhanced adherence counseling among HIV patients on antiretroviral therapy(ART) in East Africa was 63%.This value is significantly below the 95% target set by the WHO and UNAIDS under the 95-95-95 framework, emphasizing a substantial gap in achieving the desired outcome of viral load suppression in this region.
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