ArticleBMC genomics2025
Rice miRNA-mediated trans-kingdom gene regulation in pathogenic and symbiotic fungal interactions.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Plant-derived, stress-responsive microRNA mimics reduce powdery mildew infections of barley.Frontiers in plant science · 2026Article
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6 authors.
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Abstract
backgroundThe trans-kingdom movement of microRNAs (miRNAs) is a key regulatory mechanism in plant biotic interactions, influencing and modulating both pathogenic virulence and symbiotic relationships. This study employed bioinformatic analysis to predict the role of rice (Oryza sativa L.) miRNAs in regulating gene expression during interactions with the pathogenic fungi Rhizoctonia solani (R. solani) and Magnaporthe oryzae (M. oryzae), as well as the symbiotic fungus Rhizophagus irregularis (R. irregularis).
resultsPreviously reported and up-regulated rice miRNAs were identified from the literature during inoculation, and their target genes were predicted in the fungal transcriptomes. The KEGG pathway and GO enrichment analyses revealed that rice miRNAs could target genes crucial for pathogen metabolism (e.g., carbohydrate, amino acid, lipid, and xenobiotic), genetic information processing, and essential cellular processes (e.g., signal transduction, transport, catabolism, and cell growth and death), potentially impairing fungal virulence and survival. The osa-miR171 family is predicted to regulate R. irregularis genes involved in protein serine/threonine kinase activity, antiporter activity, cell division, TAP complex binding, and O-acetylhomoserine sulfhydrylase activity during symbiosis. Additionally, the osa-miR171 family targets key rice genes such as phosphate transporter, NSP2, and SCR, involved in nutrient transport, common symbiosis signaling, and root development, respectively, which are likely important for forming and regulating a symbiotic relationship. The qRT‒PCR results confirmed the up-regulation of osa-miR171h (symbiosis-related) and osa-miR167d-5p (pathogen-responsive) in rice roots inoculated with R. irregularis.
conclusionsThese findings highlight the significant role of trans-kingdom RNA regulation in plant–microbe interactions, contributing to understanding the molecular regulation, distinctions, and similarities between pathogenic and symbiotic relationships in plants. This initial study performs the first comparative trans-kingdom sRNA analysis in rice, successfully predicting and distinguishing the molecular mechanisms that drive virulence versus mutualism. This work also lays the groundwork for developing novel strategies to enhance plant disease resistance, foster beneficial symbiotic interactions, and ultimately boost agricultural yields.
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