Evidence map›Paper›PMID 41331850›Full record

ArticleCNS spectrums2025

The mediating effect of trauma and loss spectrum on the relationship between autistic traits and eating disorder symptoms among patients with borderline personality disorder.

Barbara Carpita, Chiara Bonelli, Stefano Pini, Carla Cappiello, Benedetta Nardi, Margarita Pustynnikova, Filippo Del Grande, Matteo Pioltino, Gabriele Massimetti, Ivan Mirko Cremone and 3 more

Abstract read
In one paragraph

Article in CNS spectrums, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Barbara CarpitaDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.ORCID 0000-0002-2806-6736
Chiara BonelliDepartment of Biotechnology, Chemistry and Pharmacy, https://ror.org/01tevnk56University of Siena, Siena, Italy.ORCID 0000-0002-9781-0071
Stefano PiniDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.
Carla CappielloDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.
Benedetta NardiDepartment of Biotechnology, Chemistry and Pharmacy, https://ror.org/01tevnk56University of Siena, Siena, Italy.ORCID 0000-0001-5437-7178
Margarita PustynnikovaDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.
Filippo Del GrandeDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.
Matteo PioltinoDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.
Gabriele MassimettiDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.
Ivan Mirko CremoneDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.
Mario LucianoDepartment of Psychiatry, https://ror.org/02kqnpp86University of Campania "L. Vanvitelli", Naples, Italy.
Andrea FiorilloDepartment of Psychiatry, https://ror.org/02kqnpp86University of Campania "L. Vanvitelli", Naples, Italy.
Lilliana Dell'OssoDepartment of Clinical and Experimental Medicine, https://ror.org/03ad39j10University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile increasing research is reporting a higher presence of autistic traits (AT) in patients with borderline personality disorder (BPD), both autism spectrum disorder (ASD) and BPD have been associated in literature with a vulnerability to trauma and eating disorders.

aimThe present study aimed at evaluating trauma-related symptoms and eating disorder symptoms in BPD patients with or without significant AT.

methodsA sample of 73 BPD patients was assessed with the adult autism subthreshold (AdAS) Spectrum, trauma and loss spectrum-self report (TALS-SR), and EDI-2 questionnaires.

resultsThe findings revealed that BPD patients with autistic traits (BPD-AT) scored significantly higher on the eating disorder inventory (EDI-2) and trauma and loss scale (TALS-SR) compared to those without AT. Moreover, while both AdAS Spectrum and TALS-SR scores predicted higher EDI-2 scores, a significant mediating effect of TALS-SR on the relationship between AdAS Spectrum and EDI-2 scores was reported.

conclusionThese results suggest that AT may imply more severe clinical correlates in the BPD population, including an enhanced vulnerability toward psychopathological traits frequently reported in BPD patients such as eating disorders and trauma-related symptoms, stressing the need to clarify the complex interactions among these disorders and the factors that may shape specific illness trajectories.

Indexed as

Autism Spectrum DisorderBorderline Personality DisorderFeeding and Eating DisordersAdultFemaleHumansMaleMiddle AgedSurveys and QuestionnairesYoung Adultautism spectrum disorderautistic traitsBorderline personality disordereating disorderspost-traumatic stress disorder

Identifiers

PMID41331850
PMCPMC13064728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.