ArticleCancer medicine2025
Chemotherapy Regimens and Survival in Pancreatic Cancer-A Ten-Year Single Centre Overview.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chemotherapy Regimens and Survival in Pancreatic Cancer-A Ten-Year Single Centre Overview.Cancer medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the last decade chemotherapy recommendations have changed for patients with pancreatic adenocarcinoma (PDAC) as novel regimens demonstrate better survival in selected cohorts. Herein we aim to, in a regional cohort, analyse therapy changes and possible survival benefits over a 10-year period.
methodsPatients in the southern region of Sweden diagnosed with pancreatic cancer between 2010 and 2011 (Early group) and 2018 and 2019 (Late group), were enrolled from the Swedish Pancreatic Cancer Registry. Baseline characteristics and chemotherapy regimens were obtained from medical records. Resected and palliative patients were analysed separately.
resultsA total of 323 patients with PDAC were included: 81 resected and 242 palliative, 147 within the Early and 176 within the Late group. Both palliative and resected patients in the Late group were in general older with more comorbidities and more advanced disease, although few significant differences were found. The palliative patients in the Late group received more neoadjuvant, second-line and third-line treatment; however without impact on survival. Both groups demonstrated a clear transition towards combination therapies over the years. At 2 years after diagnosis overall survival was improved in the Late resected group with 82 versus 60%, adjusted p = 0.014.
conclusionsSince 2010 there has been a shift in chemotherapy treatment for pancreatic cancer patients towards the use of combination therapies. Our data demonstrates an increase in 2-year survival for resected patients, whereas corresponding figures for the palliative patients remain unchanged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.