ArticleAnnals of dermatology2025
Proposal of Phenotypic Patterns in Facial Atopic Dermatitis: A Single-Center Retrospective Analysis of 100 Cases.
Article in Annals of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Site-Specific Characterization and Quantification of Facial Corticosteroid Addiction Dermatitis: A Multimodal Nomogram Integrating High-Frequency Ultrasonography and Transepidermal Water Loss.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Article
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3 authors.
Funding
Abstract
backgroundAtopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by eczematous lesions and pruritus. Facial and neck involvement in AD can be challenging to differentiate from other facial dermatoses, such as allergic contact dermatitis, seborrheic dermatitis, rosacea, and drug-induced facial dermatitis, complicating treatment strategies.
objectiveThis study aimed to investigate the distribution of facial involvement patterns in patients with AD and to explore the differential diagnosis, focusing on head and neck lesions.
methodsA retrospective study was conducted on 100 patients diagnosed with AD at a single medical center. Facial and neck lesions were categorized into 5 distinct patterns-periorificial, centrofacial, diffuse, patch, and mixed-based on anatomical distribution. The study also evaluated the impact of dupilumab treatment on these patterns.
resultsThe most frequently affected anatomical regions were the frontal (68%), buccal (60%), and orbital (57%) areas. The most common facial involvement pattern was periorificial (28%), followed by diffuse (24%) and centrofacial (21%). The dupilumab-treated group showed a higher frequency of the diffuse pattern compared to other treatment groups. Additionally, periorbital hyperpigmentation, Dennie-Morgan folds, and cheilitis were common minor features.
conclusionThe study identified distinct facial involvement patterns in AD, with centrofacial and periorificial patterns being the most prevalent. These findings underscore the importance of recognizing facial and neck involvement in AD for accurate diagnosis and personalized treatment. Further large-scale studies are needed to validate these results and explore the underlying mechanisms influencing facial involvement.
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