ArticleParasitology research2025
Co-delivery of spiramycin and curcumin nanoemulsions for treating acute (RH strain) and chronic (Tehran strain) toxoplasmosis in BALB/c mice.
Article in Parasitology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to develop and evaluate a nanoemulsion containing spiramycin and curcumin (NE-CS) to enhance these compounds' bioavailability and efficacy against acute and chronic toxoplasmosis in mice. Nanoemulsion containing spiramycin and curcumin (NE-CS), spiramycin nanoemulsion (NE-Spi), and a nanoemulsion without the drug (NE) were prepared via spontaneous emulsification and characterized for particle size and zeta potential. Their in vitro activity was tested against tachyzoites of T. gondii, RH strain, at different concentrations (250, 125, 62.5, and 31.25 µg/ml) and time points (30, 60, 90, and 120 min). In vivo, BALB/c mice infected with RH and Tehran strains were treated with NE-CS (25 mg/kg/day curcumin + 50 mg/kg/day spiramycin), NE-Spi (50 mg/kg/day), S-Spi, and NE, with infected/untreated mice as controls. Survival time, tachyzoite counts in peritoneal fluid (acute phase), and number and size of tissue cysts (chronic phase) were assessed microscopically. NE-CS significantly decreased the intracellular multiplication of T. gondii tachyzoites (5 ± 2.78 × 10
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