ArticleBMC musculoskeletal disorders2025
Early detection of osteoporosis in adult children of patients with proximal femur fractures: a real-world screening study.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOsteoporosis is often undiagnosed until fractures occur. A parental history of proximal femur fracture is an independent risk factor for osteoporosis in the next generation. This study evaluated whether adult children of affected patients represent a suitable target group for early screening.
methodsOver 12 months, patients aged ≥ 70 years with low-energy proximal femur fractures were enrolled. Their adult children were invited to participate. Medical history, laboratory testing, and fracture risk assessment using FRAX
resultsOf 189 patients screened, 183 were eligible (mean age 83 years). Sixty adult children participated (mean age 62 years). One had a prior osteoporosis diagnosis; nine reported previous MOF. Based on FRAX
conclusionsAdult children of patients with proximal femur fractures represent a high-risk group for osteoporosis. Nearly half met treatment thresholds, supporting targeted screening in individuals ≥ 50 years when a parent sustains such a fracture. This approach may enable earlier diagnosis and prevention of osteoporotic fractures.
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