Evidence map›Paper›PMID 41331403›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Monocyte-Differentiation-Activated Fluorescent "Scout" Probe for Precise in Vivo Detection of Vulnerable Plaque.

Zechuan Li, Jiankai Dong, Zhengkun Liu, Chaoke Zhang, Jisen Li, Ying Tao, Ding Yang, Yansong Liu, Haoting Chen, Lu Liu and 6 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zechuan LiDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Jiankai DongDepartment of Cardiology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China.
Zhengkun LiuDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Chaoke ZhangSchool of Materials Science and Engineering, University of Jinan, Jinan, 250022, China.
Jisen LiKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.
Ying TaoDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Ding YangDepartment of Radiology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, 100142, China.
Yansong LiuDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Haoting ChenDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Lu LiuDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Jingsen JiDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Feng CaoNational Clinical Research Center for Geriatric Diseases, The Second Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Dan DingKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.ORCID https://orcid.org/0000-0003-1873-6510
Qian LiuDepartment of Urology, Tianjin First Central Hospital, Tianjin, 300192, China.
Chenxing FuDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Weisheng GuoDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.ORCID https://orcid.org/0000-0002-8064-357X

Funding

Educational Commission of Guangdong Province of China key Project 2020ZDZX2001National Natural Science Foundation of China 32301170National Natural Science Foundation of China 82302264National Natural Science Foundation of China 82372128National Natural Science Foundation of China U23A20489Natural Science Foundation for Distinguished Young Scholars grant of Guangdong Province 2023B1515020071
6 · The paper itself

Abstract

Precise identification of vulnerable plaque (VAP) is essential for the prevention of acute cardiovascular diseases, yet current molecular probes are hampered by poor VAP lesion penetration and high background. Here, the innate tropism of circulating inflammatory monocytes for VAP, and their differentiation-driven expression of legumain (Lgmn) in response to the VAP microenvironment is exploited. A monocyte differentiation-activated fluorescent (MDAF) probe is conceived that hitchhikes monocytes to precisely migrate to VAP and is activated by Lgmn during monocyte differentiation. This activation triggers in situ self-assembly, resulting in spatiotemporally controlled aggregation-induced emission (AIE) fluorescence signals, and turning the monocyte itself into an on-site "scout" that reports plaque instability. In Apoe

Indexed as

Fluorescent DyesMonocytesOptical ImagingPlaque, AtheroscleroticAnimalsCell DifferentiationHumansMiceMice, Inbred C57BLFluorescent Dyesaggregation‐induced emissionatherosclerosiscell‐mediated deliverymolecular imagingmonocyte dynamic differentiation

Identifiers

PMID41331403
PMCPMC12903971

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.