ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Structural Variation and 3D Genome-Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Structural Variation and Its Roles in Plant Genomes.Plants (Basel, Switzerland) · 2026Review
- Genomic diversity and the domestication history of cotton (Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pan-3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Structural Variation and 3D Genome-Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Cotton domestication has driven remarkable improvements in fiber quality; however, the integrative roles of structural variation (SV), 3D genome architecture, and epigenetic regulation in this process remain poorly understood. Here, the genome assembly of wild (yucatanense, Yuc) and cultivated cotton (Xinluzao 61, XLZ61) is first reported. A total of 35 050 InDels and 165 inversions are identified, and 86.6% of these SVs are accumulated in differential topologically associating domain regions, indicating the important role of SV in 3D genome remodeling. Comparative analysis also yielded 199 359 differential DNA methylation regions and 2 092 787 differential RNA methylation loci, collectively affecting 44.7% of differentially expressed genes. Notably, SV-associated methylation changes had stronger effects on gene expression than epigenetic modifications alone. Construction of an ultra-dense genetic map comprising 13 602 620 SNP loci and QTL mapping further revealed SVs and 3D genome remodeling-driven DNA/RNA methylation divergence to contribute to fiber length in domesticated cotton, demonstrating how SV reshapes trait variation. Collectively, these findings elucidated the crucial role of the "SVs-3D genome remodeling-epigenetic modifications-gene expression" cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.