Evidence map›Paper›PMID 41331340›Full record

ArticleScientific reports2025

AI assistance improves reader agreement in digital mammography: A multireader crossover study of general and breast subspecialty radiologists.

Mohadese Ahmadzade, Hamidreza Rouientan, Nastaran Abdi, Masoomeh Norouzi, Maryam Hakimi, Maryam Bahrambeigi, Ensi Khalili Pouya, Fatemeh Bahmanyar, Sepideh Haghi, Fatemeh Abbasi and 7 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mohadese AhmadzadeDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Hamidreza RouientanDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Nastaran AbdiDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Masoomeh NorouziDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Maryam HakimiDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Maryam BahrambeigiDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Ensi Khalili PouyaDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Fatemeh BahmanyarDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Sepideh HaghiDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Fatemeh AbbasiDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Hasan MadadiDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Khadijeh BakhtavarDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Hamid LaaliniaDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Nasrin AhmadinejadDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Parham RabieeDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran.
Fatima MoosavianDepartment of Radiology, Tehran University of Medical Sciences, Tehran, Iran.
Shahram AkhlaghpoorDepartment of Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, Iran. Shahram_ak@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to evaluate the impact of artificial intelligence (AI) on inter- and intra-rater agreement in mammography interpretation, comparing improvements in reliability between general and breast subspecialty radiologists in a clinical setting. This study was conducted using anonymized digital mammograms from 65 women aged 40-74 years undergoing routine screening. Fourteen radiologists, grouped by experience, assessed images in a multi-reader, multi-case, crossover design with and without AI assistance. Statistical analyses, including Cohen's Kappa and meta-analysis, measured inter- and intra-rater reliability across radiological variables. AI assistance significantly improved agreement with the gold standard for both general and breast subspecialty radiologists. Variables such as BI-RADS breast density and lesion location showed marked improvements, particularly among general radiologists, where Kappa values for BI-RADS breast density rose from 50.01% to 81.38% with AI. Subspecialists demonstrated smaller performance gains, likely due to higher baseline accuracy. AI also enhanced intra-rater reliability and reduced variability across experience levels. These findings support AI's role as a valuable adjunct in breast cancer screening, addressing the shortage of experienced radiologists. Further research in real-world settings is necessary to confirm these results and optimize AI integration.

Indexed as

Artificial IntelligenceBreastBreast NeoplasmsMammographyRadiographic Image Interpretation, Computer-AssistedRadiologistsAdultAgedCross-Over StudiesEarly Detection of CancerFemaleHumansMiddle AgedObserver VariationReproducibility of Results

Identifiers

PMID41331340
PMCPMC12796293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.