Evidence map›Paper›PMID 41331322›Full record

ArticleScientific reports2025

Changes in social reward across adolescence in male mice.

Zofia Harda, Marta Klimczak, Klaudia Misiołek, Magdalena Chrószcz, Łukasz Szumiec, Maria Kaczmarczyk-Jarosz, Aleksandra Rzeszut, Rafał Ryguła, Barbara Ziółkowska, Jan Rodriguez Parkitna

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Adolescent mice exhibit lower reward sensitivity than adults.Frontiers in behavioral neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zofia HardaDepartment of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Marta KlimczakDepartment of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Klaudia MisiołekDepartment of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Magdalena ChrószczDepartment of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Łukasz SzumiecDepartment of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Maria Kaczmarczyk-JaroszDepartment of Physiology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Aleksandra RzeszutDepartment of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Rafał RygułaAffective Cognitive Neuroscience Laboratory, Department of Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland.
Barbara Ziółkowska *Department of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland. nfziolko@cyf-kr.edu.pl.
Jan Rodriguez Parkitna *Department of Molecular Neuropharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna Street 12, Kraków, 31-343, Poland. janrod@if-pan.krakow.pl.

Funding

Narodowe Centrum Nauki 2016/21/B/NZ4/00198
6 · The paper itself

Abstract

In humans, adolescence is a time of dynamic behavioral and emotional changes, including a transient decrease in affect associated with being among family members. It is not clear if a similar change occurs in rodent species used to model human psychiatric disorders. Here, we investigated the developmental profile of the rewarding value of interactions with siblings across adolescence in male mice, using the social conditioned place preference task. We found that the reward value of social interactions followed a similar course to that in humans: high in early adolescence, it decreased in mid-adolescence and returned to the initial level in late adolescence. The observed change was specific to social interaction, as no age-dependent changes in preference for cocaine-conditioned context were detected. Taken together, these data show similarities between mice and humans in developmental changes in sensitivity to the rewarding effects of interactions with familiar kin.

Indexed as

Behavior, AnimalRewardSocial BehaviorSocial InteractionAnimalsCocaineMaleMiceMice, Inbred C57BLCocaine

Identifiers

PMID41331322
PMCPMC12789513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.