ArticleScientific reports2025
Physiological responses and histological alterations induced by pollution in the Nile tilapia from the Rosetta branch of the River Nile, Egypt.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Physiological and histopathological responses of Pangasianodon hypophthalmus to ammonia exposure at varying thermal regimes.Scientific reports · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Nile River is the primary source of freshwater in Egypt and supports nearly all the anthropogenic activities in the region and, consequently, it is highly susceptible to pollution from diverse sources. Aquatic ecosystems in the Nile basin face increasing threats originated from pollution and seasonal fluctuations, both of which can profoundly affect the health and resilience of fish populations. Hence, addressing this issue is a must. This study investigated the impact of heavy metals (Fe, Zn, Cu, Cr and Cd) on key physiological and biochemical parameters for the Nile tilapia, Oreochromis niloticus sampled from two sites on the Rosetta Branch of the River Nile: El-Qanater (reference site) and El-Qatta (polluted site) during summer and winter of 2023. In addition, histological analysis was conducted on vital organs covering the winter season. Both site and season were detected with impacts on the hormonal concentrations in the fish samples. Compared to the reference site, fish individuals from the polluted site exhibited pronounced alterations in hormonal balance, with elevated cortisol levels and a marked decline in thyroid hormones (T3 and T4), while TSH levels were increased, particularly during winter. Elevated serum glucose, total protein, and albumin levels were evidenced for metabolic stress. Liver enzyme activity (ALT and AST) and kidney function biomarkers (urea, uric acid, and creatinine) were significantly increased, especially in winter. Profound responses to pollution were recorded with higher levels of SOD, CAT, GPx, and GST, aligned with a substantial decline in GSH levels. Moreover, higher malondialdehyde (MDA) levels were detected in winter. For fish organs histologically examined, a severe damage was remarkably observed in liver, gills, and kidney of fish from El-Qatta site. This study reveals the combined impact of pollution and seasonal changes on the Nile tilapia health, emphasizing the need for continuous monitoring and effective pollution control. Implementing targeted water quality programs in the Rosetta Branch is recommended to preserve fish health, biodiversity, and sustainable fisheries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.