Evidence map›Paper›PMID 41331287›Full record

ArticleNeurogastroenterology and motility2026

Influence of Sacral and Thoracolumbar Spinal Nerve Electrical Stimulation on Colonic Motility in Anesthetized Yucatan Male Pigs.

Muriel Larauche, Yushan Wang, Yan-Peng Chen, Xu Han, Karim Atmani, James C Y Dunn, Wentai Liu, Mulugeta Million

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muriel LaraucheUCLA, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-3320-3675
Yushan WangDepartment of Bioengineering, UCLA, Los Angeles, California, USA.
Yan-Peng ChenDepartment of Bioengineering, UCLA, Los Angeles, California, USA.
Xu HanDepartment of Bioengineering, UCLA, Los Angeles, California, USA.
Karim AtmaniUCLA, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
James C Y DunnDepartment of Surgery and Bioengineering, Stanford University, Stanford, California, USA.
Wentai LiuDepartment of Bioengineering, UCLA, Los Angeles, California, USA.
Mulugeta MillionUCLA, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous SystemOT2OD024899 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MULUGETA, MILLION, TACHE, YVETTE FRANCE · 2017 to 2021
$13.1M
Chen Soon-Shiong Bionic Engineering Center endowment fundDigestive Diseases Research Center 5P30DK41301-18NIDDK NIH HHS P30 DK041301NIH HHS 1OT2OD024899-01NIH HHS OT2 OD024899
6 · The paper itself

Abstract

backgroundColon displays structural and functional diversity. However, the region-specific motility effects of spinal nerves on the colon are unclear. We mapped the regional colonic motor response to thoracolumbar (T12-L1) (TLNS) and sacral (S1-S4) (SNS) roots nerve electrical stimulation (ES) in an anesthetized porcine model, with or without concomitant afferent (AB) or efferent (EB) transmission block.

methodsAdult male Yucatan pigs (n = 16) underwent a laminectomy followed by unilateral (left root) SNS (S1-S4, 30 Hz, 0.3 ms, 0.5 mA, PT, 30 s ON/90 s OFF) or with concomitant AB or EB (40 kHz, 0.1 ms, 2 mA). In a separate group (n = 7), TLNS (T12-L1, 10 Hz, 0.3 ms, 0.5 mA, continuous or 30 Hz, 0.3 ms, 0.5 mA, PT, 30 s ON/90 s OFF) of the left root concomitant with or without EB was applied. Proximal (pC), transverse (tC), distal (dC) colon and anal canal (AC) luminal manometry were monitored before, during and after stimulation. Area under the curve of contraction (AUC), luminal pressure heat maps, and contraction spectral analysis were analyzed. KEY

resultsS2 ES increased the power of the contraction frequency spectrum in both dC and AC during stimulation and increased the AUC of contraction in dC and AC during and post-stimulation. AB and EB partially reduced dC, while EB abolished the increase in AC. In contrast, S1, S3, or S4 ES as well as TLNS had little effect on motility.

conclusionsIn anesthetized male pigs, S2 ES induces a robust motility response in the distal colon via the central network while in the anal canal via efferent pathways.

Indexed as

ColonGastrointestinal MotilitySpinal NervesAnimalsElectric StimulationMaleSwinecolon motilitymanometrysacral nerve root stimulationthoracolumbar nerve root stimulation

Identifiers

PMID41331287
PMCPMC12815001

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.