Evidence map›Paper›PMID 41331164›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Global genomic characteristics of mobile colistin resistance mcr genes in Enterobacterales from companion animals.

João Pedro Rueda Furlan, Che Song, Xinyue Zhai, Qian Tong, Eliana Guedes Stehling, Nilton Lincopan, Zhi Ruan, Fábio Parra Sellera

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

João Pedro Rueda FurlanDepartment of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. joao.furlan@academico.ufpb.br.ORCID http://orcid.org/0000-0003-2516-1129
Che SongSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Xinyue ZhaiSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Qian TongLaboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Eliana Guedes StehlingDepartment of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-4362-3203
Nilton LincopanAntimicrobial Resistance Institute of São Paulo (ARIES), São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0161-5800
Zhi RuanDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. r_z@zju.edu.cn.ORCID http://orcid.org/0000-0001-8648-4592
Fábio Parra SelleraSchool of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil. fabiopsellera@gmail.com.ORCID http://orcid.org/0000-0002-4725-0125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mobile colistin resistance (mcr) genes, initially described in livestock and humans, remain less frequently reported in companion animals. We conducted a global genomic survey of 14,643 bacterial genomes retrieved from the NCBI National Database of Antibiotic Resistant Organisms and identified 105 (0.7%) mcr-positive Enterobacterales from dogs (79.0%) and cats (21.0%). Escherichia coli (73.3%) and the Enterobacter cloacae complex (20.9%) predominated, with the mcr-1 and mcr-9 variants being the most frequent. Most genomes originated from Asia, Europe, and North America, reflecting the uneven geographic distribution of sequenced mcr-positive strains. Genomic analysis revealed a genetic plurality and co-occurrence of mcr genes with CTX-M-type extended-spectrum β-lactamases (46.6%), carbapenemases (5.7%), and 16S rRNA methyltransferases (8.6%), particularly in international high-risk clones. These findings underscore the diversity and epidemiological relevance of mcr-positive bacteria in pets, reinforcing the need for closer monitoring through One Health-based surveillance.

Indexed as

Anti-Bacterial AgentsColistinDrug Resistance, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsPetsAnimalsBacterial Proteinsbeta-LactamasesCat DiseasesCatsDog DiseasesDogsGenome, BacterialGenomicsMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesColistinColistinmcrMDR bacteriaOne HealthPetsPolymyxins

Identifiers

PMID41331164

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.