Evidence map›Paper›PMID 41330944›Full record

ReviewNPJ systems biology and applications2025

Mammalian synthetic gene circuits for biopharmaceutical development & manufacture.

Sheryl Li Yan Lim, Sofia Gialamoidou, Rajinder Kaur, Ioscani Jimenez Del Val

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NPJ systems biology and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sheryl Li Yan LimSchool of Chemical & Bioprocess Engineering, University College Dublin D04 V1W8, Dublin, Ireland.
Sofia GialamoidouSchool of Chemical & Bioprocess Engineering, University College Dublin D04 V1W8, Dublin, Ireland.
Rajinder KaurSchool of Chemical & Bioprocess Engineering, University College Dublin D04 V1W8, Dublin, Ireland.
Ioscani Jimenez Del ValSchool of Chemical & Bioprocess Engineering, University College Dublin D04 V1W8, Dublin, Ireland. ioscani.jimenezdelval@ucd.ie.

Funding

Science Foundation Ireland 20FFP-P8864
6 · The paper itself

Abstract

This paper reviews the design and application of mammalian synthetic gene circuits for biopharmaceutical manufacturing. It discusses key design principles and outlines transcription factors, DNA-binding proteins, and RNA as input and regulatory modules, while also presenting computational modelling as a driver for circuit optimisation. The review highlights potential applications towards the production of next-generation biotherapeutics by providing examples on monoclonal antibody glycosylation control, CAR-T cell therapy safety, and gene therapy viral vector yields.

Indexed as

BiopharmaceuticsGene Regulatory NetworksGenes, SyntheticSynthetic BiologyAnimalsAntibodies, MonoclonalGenetic TherapyHumansMammalsAntibodies, Monoclonal

Identifiers

PMID41330944
PMCPMC12764465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.