Evidence map›Paper›PMID 41330933›Full record

ArticleNature communications2025

Structural mechanism of the Retron-Eco7 anti-phage defense system.

Junichiro Ishikawa, Kanta Yoneyama, Aa Haeruman Azam, Asuteka Nagao, Yoshihisa Mitsuda, Ren Nakazaki, Kotaro Chihara, Masahiro Hiraizumi, Keitaro Yamashita, Tsutomu Suzuki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Advances in phage therapy forFrontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junichiro Ishikawa *Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4112-4168
Kanta Yoneyama *Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0009-0003-1731-7637
Aa Haeruman Azam *Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan.
Asuteka NagaoDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Yoshihisa MitsudaDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Ren NakazakiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Kotaro ChiharaResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2694-2560
Masahiro HiraizumiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4340-2937
Keitaro YamashitaStructural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5442-7582
Tsutomu SuzukiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9731-1731
Kotaro KigaResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan. k-kiga@niid.go.jp.ORCID http://orcid.org/0000-0002-0248-6951
Hiroshi NishimasuDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. nisimasu@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-2505-1416

Funding

Japan Agency for Medical Research and Development (AMED) 23wm0325065MEXT | Japan Society for the Promotion of Science (JSPS) 21H05281MEXT | Japan Society for the Promotion of Science (JSPS) 22H00403
6 · The paper itself

Abstract

Retrons are prokaryotic genetic elements involved in anti-phage defense and consist of a non-coding RNA, a reverse transcriptase (RT), and various effector proteins. Retron-Eco7 (previously known as Retron-Ec78) from Escherichia coli encodes two effector proteins (the PtuA ATPase and the PtuB nuclease) and degrades the host tRNA

Indexed as

BacteriophagesEscherichia coliEscherichia coli ProteinsAdenosine TriphosphatasesCryoelectron MicroscopyDNA, Single-StrandedModels, MolecularRNA-Directed DNA PolymeraseAdenosine TriphosphatasesDNA, Single-StrandedEscherichia coli ProteinsRNA-Directed DNA Polymerase

Identifiers

PMID41330933
PMCPMC12673091

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.