Evidence map›Paper›PMID 41330909›Full record

ArticleNature communications2025

The risk of human- and mammal-infecting tick-borne viruses in northwest China and adjacent countries.

Hong Zhou, Hengcong Liu, Yun-Xiao Wang, Shanshan Zhao, Moujian Guo, Mingxue Cui, Jianjun Chen, Juan Li, Suwen Wang, Xudong Zhang and 11 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hong Zhou *School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China. zhouh@sdfmu.edu.cn.ORCID http://orcid.org/0000-0002-8164-0020
Hengcong Liu *Shanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-2591-2201
Yun-Xiao Wang *Shanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0009-0006-1808-5163
Shanshan Zhao *Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the XPCC, School of Medicine, Shihezi University, Shihezi, China.ORCID http://orcid.org/0000-0003-2334-4597
Moujian GuoRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-8517-543X
Mingxue CuiKey Laboratory of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0009-0007-0007-6231
Jianjun ChenCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID http://orcid.org/0000-0002-2966-2388
Juan LiSchool of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0000-0003-0905-7188
Suwen WangKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the XPCC, School of Medicine, Shihezi University, Shihezi, China.ORCID http://orcid.org/0000-0001-5838-3823
Xudong ZhangShandong Public Health Clinical Center, Shandong University, Ji'nan, China.ORCID http://orcid.org/0009-0008-7462-0372
Jiaqi QinSchool of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0009-0006-4194-152X
Ziman LvKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the XPCC, School of Medicine, Shihezi University, Shihezi, China.ORCID http://orcid.org/0009-0008-8497-414X
Zhenghai MaCollege of Life Science and Technology, Xinjiang University, Urumqi, China.ORCID http://orcid.org/0000-0002-0930-7696
Ruiling ZhangSchool of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, China.ORCID http://orcid.org/0000-0002-2856-3548
Bin ZhangCollege of Life Sciences and Technology, Inner Mongolia Normal University, Hohhot, China.ORCID http://orcid.org/0000-0001-8702-9022
Wen ZhengShanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-6451-4770
Jingkai JiSchool of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China.ORCID http://orcid.org/0000-0002-9264-7746
Tianze WangShanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0009-0009-2871-0374
Edward C HolmesSchool of Medical Sciences, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0001-9596-3552
Yuan-Zhi WangKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the XPCC, School of Medicine, Shihezi University, Shihezi, China. wangyuanzhi621@126.com.ORCID http://orcid.org/0000-0002-7500-022X
Weifeng ShiShanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. shiwf@ioz.ac.cn.ORCID http://orcid.org/0000-0002-8717-2942

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32325003, 82202516, 82472276, 82260399, and 31970174Taishan Scholar Foundation of Shandong Province tsqn202306264
6 · The paper itself

Abstract

The prevalence, evolution, and disease risk of pathogenic tick-borne viruses (TBVs) remains poorly understood in northwest China and adjacent countries, which are endemic for several TBVs of public health importance. Herein, we perform meta-transcriptomic sequencing of >9600 ticks collected across this vast geographic area to identify 92 RNA viruses and assemble 1567 viral genomes from 28 different tick species, including ten human- and mammal-infecting TBVs. Tacheng tick virus 1 (TcTV-1), Tacheng tick virus 2 (TcTV-2), Tamdy virus (TAMV), and Crimean-Congo hemorrhagic fever virus (CCHFV) are the most common human-infecting TBVs detected. We also report several pathogenic TBVs not previously identified in China (Burana virus and Bhanja virus), Kazakhstan (TcTV-1), and northwest China (Wad Medani virus and Alongshan virus). We predict a significant increase in the number of high-risk regions for the four major tick vectors of pathogenic TBVs, and the distribution of TAMV, TcTV-1, TcTV-2, and CCHFV, with 65.4% of the counties in this region identified as high risk for CCHFV. Therefore, the real disease burden caused by TBVs in northwest China and adjacent countries may be more underestimated than appreciated, and we call for strengthened field surveys and epidemiological surveillance in this vast region.

Indexed as

RNA VirusesTick-Borne DiseasesTicksAnimalsArachnid VectorsChinaGenome, ViralHemorrhagic Fever Virus, Crimean-CongoHumansMammalsPhylogeny

Identifiers

PMID41330909
PMCPMC12780119

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.