ArticleGenome biology and evolution2025
DNA Circles as Vehicles for Genes to Evade Chromosomal Discipline.
Article in Genome biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
In this Perspective article, we follow the journey of a gene that breaks free from its stringent chromosomal transmission dynamics to become an independently multiplying agent on so-called extrachromosomal circular DNA (ecDNA/eccDNA). We discuss how the release of a gene from its chromosomal anchor can affect its dosage, regulatory context, and potential evolutionary trajectory before examining the phenotypic implications for unicellular and multicellular eukaryotes that transmit genes on circular DNA. We also briefly explore the fundamental difference between circularized genes in flowering plants (angiosperms) and mammals (primarily cancer) concerning somatic and germline inheritance.
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