ArticleJournal of cosmetic dermatology2025
Finasteride Use Does Not Lead to Depression or Suicide: Insights From a Large-Scale Cohort Study and Mendelian Randomization Analysis.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Finasteride Use Does Not Lead to Depression or Suicide: Insights From a Large-Scale Cohort Study and Mendelian Randomization Analysis.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundFinasteride is widely used in clinical practice to treat androgenetic alopecia (AGA). However, its potential role in increasing the risk of depression and suicidal tendencies among users remains a topic of significant controversy. PATIENTS AND
methodsFive datasets were used as exposures and ten as outcomes. Mendelian randomization (MR) is used to evaluate the causal relationship between finasteride use and the risk of depression or suicide. We also utilized a COX regression model on the large-scale UK Biobank cohort to explore the potential correlation between finasteride use and the risk of depression or suicide.
resultsMR analysis reported that Finasteride prescription is not related to depression or suicide after the false discovery rate (FDR) correction. COX regression analysis also showed that finasteride use is not significantly associated with depression or suicide events in the UK Biobank cohort, whether or not covariates were considered.
conclusionThe existing evidence does not support the relevance between systemic use of finasteride and increased risk of depression or suicide.
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Registered trials
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