ReviewTrends in neurosciences2026
Reconstructing the human brain's wiring diagram from axons up.
Review in Trends in neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain.bioRxiv : the preprint server for biology · 2026Article
- [Advances in the application of individualized white-matter functional networks in children and adolescents with attention-deficit/hyperactivity disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsReview
- Massively parallelized brain tractography using compute clusters, supercomputers, and graphics processing units.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The human brain's long-range axonal connections are the scaffolding for communication across functionally distinct areas. Yet knowledge of the human brain's wiring diagram remains limited, largely due to longstanding technological challenges. Recent innovations in microscopy may now enable mapping human brain connectivity at the mesoscale (groups of neurons and their axons). In this review we describe the challenges of generating the wiring diagrams of the human brain, avenues forward, and reasons why such an effort is so important. We argue for building a human mesoscale connectome via a multimodal, multi-species, axon-centric approach, focusing on where axons begin and end to reconstruct connectivity across spatial resolutions. Finally, we consider the utility of a potential exemplar connectome for both clinical applications and research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.