ArticleEuropean journal of haematology2026
Enhanced Detection of Multiple Myeloma Cells by Next-Generation Flow Cytometry Following Density Gradient Medium Separation.
Article in European journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Enhanced Detection of Multiple Myeloma Cells by Next-Generation Flow Cytometry Following Density Gradient Medium Separation.European journal of haematology · 2026Article
- Bone marrow hemodilution assessment in multiple myeloma MRD by next generation flow cytometry - a mini review.Frontiers in oncology · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
introductionFollowing treatment, relapse of Multiple Myeloma (MM) occurs due to measurable residual disease (MRD). As therapeutic options expand, advances in response assessment become more critical, necessitating more sensitive MRD detection methods.
methodThis study aimed to improve the efficiency and sensitivity of a flow cytometry assay for MM MRD detection in blood and bone marrow. To achieve this, three pre-enrichment methods were compared using 32 samples from patients with active MM and 122 samples from MM patients in remission. The methods compared were the Euroflow recommended erythrocyte bulk lysis (BL) method, density gradient medium (DGM) separation and negative selection (NS).
resultsBy removing granulocytes, DGM facilitated the processing of a larger starting quantity of white blood cells (WBCs) (> 60 × 10
conclusionPre-enrichment via DGM separation can cost-effectively reduce sample processing times and significantly increase the analytical sensitivity of MM MRD analysis.
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