ArticleAllergy, asthma & immunology research2025
Bronchodilator Response of TEV/FEV3 and Its Implications in Pediatric Asthma.
Article in Allergy, asthma & immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The diagnosis of asthma in children is challenging due to limitations of conventional spirometry, which primarily assesses large airway function and requires considerable patient effort. Terminal expiration volume (TEV)/forced expiratory volume in 3 seconds (FEV3) has been proposed as a new metric that may help assess small airway dysfunction, where TEV represents the volume difference between FEV3 and forced expiratory volume in 1 seconds (FEV1) and reflects terminal expiratory airflow. We aimed to evaluate the bronchodilator response (BDR) of TEV/FEV3 (BDR-TEV/FEV3) as an index reflecting variable small airway obstruction in children. This retrospective study included 1,199 children who underwent both spirometry and bronchial provocation testing for asthma at a tertiary hospital between January 2017 and December 2019. BDR-TEV/FEV3 was compared according to asthma status and severity. The findings were verified using an external validation group (n = 105). We also explored the association between BDR-TEV/FEV3 and established indices of airway inflammation. BDR-TEV/FEV3 was significantly higher in children with asthma than in those without asthma (3.74% vs. 1.81%,
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