Evidence map›Paper›PMID 41330618›Full record

ArticleLife science alliance2026

GPR88 localization to primary cilia in neurons is cell-type specific.

Yenni H Li Guan, Brigitte L Kieffer, Mark von Zastrow, Aliza T Ehrlich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yenni H Li GuanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Brigitte L KiefferINSERM UMR-S 1329, Strasbourg Translational Neuroscience and Psychiatry, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg (UNISTRA), Strasbourg, France.
Mark von ZastrowDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Aliza T EhrlichDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA Aliza.ehrlich@ucsf.edu.ORCID 0000-0001-7507-1100

Funding

PROTEINS REGULATING ENDOCYTOSIS OF OPIOID RECEPTORSR01DA012864 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark E Von Zastrow · 2000 to 2026
$7.9M
Membrane Trafficking of Opioid and Adrenergic ReceptorsR01DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2014 to 2023
$4.6M
GPR88 localization to primary cilia and its impact on striatal cAMP signalingR01MH120212 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2019 to 2023
$2.0M
Neuronal Gαi-GPCR targeting to primary cilia and impact on cAMP mediated transcriptionK01MH123757 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EHRLICH, ALIZA TOBY · 2020 to 2024
$792k
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012012N01MH012012 · NIMH · DUKE UNIVERSITY MEDICAL CENTER · 2002 to 2004
–
NIDA NIH HHS R01 DA010711NIDA NIH HHS R01 DA012864NIMH NIH HHS K01 MH123757NIMH NIH HHS N01 MH012012NIMH NIH HHS R01 MH120212
6 · The paper itself

Abstract

GPR88 is an orphan G protein-coupled receptor that regulates dopamine neurotransmission and is a target for neuropsychiatric disorders. In addition to the somatic membrane, GPR88 can localize to the primary cilium, a membrane microdomain known for dynamically enriching receptors and signaling molecules. However, the distribution of GPR88 in neuronal primary cilia remains uncharacterized. Here, we characterize GPR88 distribution at primary cilia in two brain areas. We show that in the striatum, GPR88 localizes both to somatodendritic and primary cilia compartments on inhibitory GABAergic medium spiny neurons. In contrast, in the somatosensory cortex, GPR88 localizes to somatodendritic and nuclear compartments and not primary cilia of excitatory spiny stellate neurons. In addition, we found that cilia density and length were similar between

Indexed as

CiliaNeuronsReceptors, G-Protein-CoupledAnimalsBrainCorpus StriatumMaleMiceMice, Inbred C57BLMice, KnockoutSomatosensory CortexGpr88 protein, mouseReceptors, G-Protein-Coupled

Identifiers

PMID41330618
PMCPMC12672383

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.