ArticleJournal for immunotherapy of cancer2025
PROTAC-based nanoantigens promote cross-presentation and trafficking of dendritic cell vaccine for enhanced antitumor efficacy.
Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Opportunities and challenges for cancer immunotherapy based on antigen cross-presentation.Annals of medicine · 2026Review
- Therapeutic cancer vaccines: development, challenges, and future perspectives.Acta pharmacologica Sinica · 2026Review
- PROTAC-Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
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Authors and funding
7 authors.
Funding
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Abstract
backgroundAs the most powerful professional antigen-presenting cell, dendritic cells (DCs), can effectively activate tumor-specific cytotoxic T lymphocyte responses through antigen cross-presentation (XPT), which involves endosome escape and subsequent degradation by ubiquitin-proteasome system of the exogenous tumor antigen in cytosol. Unfortunately, this important function is often compromised in the tumor microenvironment.
methodsTo recover the function of DCs in the antitumor settings, in the present study, we applied PROTAC (proteolysis-targeting chimera) principle in DC vaccine design by chemically linking a small molecular ligand of E3 ubiquitin ligase lenalidomide to a protein antigen ovalbumin (OVA), wrapped in membrane-penetrating nanoparticles calcium carbonate (CaCO
resultsThe antitumor efficacy of the DC vaccines prepared by the chimeric antigen-containing nanoparticles, lenalidomide-OVA-CaCO
conclusionsTogether, we established a proof of concept for PROTAC in the DC vaccine design by linking E3 ligase to a protein model antigen, which can be readily replaced with other identified pathogenic antigens to elicit robust cytotoxic immune responses against tumors or viral diseases, and thus has serious implications in the clinics.
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