Evidence map›Paper›PMID 41330477›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2026

Divergent humoral immune signatures in response to Klebsiella pneumoniae bacteremia.

Paeton L Wantuch, Nadia Wattad, David A Rosen

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Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paeton L WantuchDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Nadia WattadDepartment of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St. Louis, MO, USA.
David A RosenDepartment of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: rosend@wustl.edu.

Funding

Protective immunity elicited by distinct polysaccharide antigens of classical and hypervirulent KlebsiellaR01AI175038 · NIAID · WASHINGTON UNIVERSITY · PI ROSEN, DAVID A. · 2023 to 2025
$3.5M
NIAID NIH HHS R01 AI175038
6 · The paper itself

Abstract

objectivesKlebsiella pneumoniae is an increasingly threatening global pathogen with high rates of antibiotic resistance and no licensed vaccines available. Despite its worldwide importance, little is known about the human adaptive immune response to K. pneumoniae infection.

methodsHerein we observed the longitudinal antibody responses of three immunocompetent patients hospitalized with K. pneumoniae bacteremia. We analyzed the human serum for antibody titers and in vitro functionality. Further, serum function was evaluated via an in vivo mouse model.

resultsWe found that in each case, anti-K. pneumoniae antibodies against the infecting strain were still detectable a year after the initial infection. Serum bactericidal assays revealed a wide spectrum of antibody functionality against the inciting strains in vitro. Finally, mice were passively immunized with three patients' sera; one of these sera protected mice from lethal bacteremia challenge with its matched K. pneumoniae strain.

conclusionsThese results highlight variability in the human humoral immune response to K. pneumoniae bacteremia and stress the importance of studying multiple aspects of antibody-mediated protection to inform vaccine design.

Indexed as

Antibodies, BacterialBacteremiaImmunity, HumoralKlebsiella InfectionsKlebsiella pneumoniaeAgedAnimalsDisease Models, AnimalFemaleHumansImmunization, PassiveMaleMiceMiddle AgedAntibodies, BacterialBloodstream infectionsImmune responseKlebsiella pneumoniaeSepsis mouse model

Identifiers

PMID41330477
PMCPMC12879011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.