Evidence map›Paper›PMID 41330456›Full record

ArticleBrain, behavior, and immunity2026

Sexual minority adults exhibit greater inflammation than heterosexual adults in the context of depressive symptoms and anxiety: Pathways to health disparities.

Lisa M Christian, Rebecca R Andridge, Juan Peng, Nithya P Kasibhatla, Thomas W McDade, Tessa Blevins, Steve W Cole, Wendy D Manning, Claire M Kamp Dush

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Self-rated health and inflammation: Associations among partnered sexual minority and heterosexual adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lisa M ChristianDepartment of Psychiatry & Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA; The Institute of Brain, Behavior, and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: Lisa.Christian@osumc.edu.
Rebecca R AndridgeDivision of Biostatistics, College of Public Health, USA College of Medicine, The Ohio State University Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Juan PengCenter for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Nithya P KasibhatlaThe Institute of Brain, Behavior, and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Thomas W McDadeDepartment of Anthropology, Northwestern University, Evanston, IL, USA; Institute for Policy Research, Northwestern University, Evanston, IL, USA.
Tessa BlevinsThe Institute of Brain, Behavior, and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Psychology, The Ohio State University, Columbus, OH, USA.
Steve W ColeDepartment of Psychiatry & Biobehavioral Sciences and Medicine, UCLA School of Medicine, Los Angeles, CA, USA; Minnesota Population Center, University of Minnesota, Minneapolis, MN, USA.
Wendy D ManningDepartment of Sociology, Bowling Green State University, Bowling Green, OH, USA.
Claire M Kamp DushMinnesota Population Center, University of Minnesota, Minneapolis, MN, USA; Department of Sociology, University of Minnesota, Minneapolis, MN, USA.

Funding

Institute for Population ResearchP2CHD058484 · NICHD · OHIO STATE UNIVERSITY · PI HAYFORD, SARAH R · 2014 to 2023
$5.0M
Minnesota Population Center Science and Technical CoreP2CHD041023 · NICHD · UNIVERSITY OF MINNESOTA · PI THERESA LOUISE OSYPUK · 2016 to 2026
$4.3M
Mechanisms Underlying Sexual Minority Health Disparities in the United StatesR01HD094081 · NICHD · UNIVERSITY OF MINNESOTA · PI Claire M Kamp Dush, WENDY D. MANNING · 2018 to 2026
$4.3M
Comprehensive Biological Data in NCHAT BIO: Chronic Stress, Inflammation, and Epigenetic AgingR01AG096920 · NIA · OHIO STATE UNIVERSITY · PI Lisa Michelle Christian, Claire M Kamp Dush · 2025 to 2026
$2.9M
Unequal Parenthoods: Population Perspectives on Gender, Race, and Sexual Minority Disparities in Family Stress and Health During CrisesU01HD108779 · NICHD · UNIVERSITY OF MINNESOTA · PI KAMP DUSH, CLAIRE M, MEIER, ANN M · 2021 to 2025
$2.1M
Computing and Data CoreP2CHD050959 · NICHD · BOWLING GREEN STATE UNIVERSITY · PI BROWN, SUSAN L. · 2016 to 2021
$1.2M
The National Couples Health and Time Use Stress Biology Study (NCHAT-BIO): Biobehavioral Pathways to Population Health Disparities in Sexual MinoritiesR21MD018158 · NIMHD · OHIO STATE UNIVERSITY · PI CHRISTIAN, LISA MICHELLE, MORGAN, ETHAN · 2023 to 2024
$464k
Archiving for Minority Health: Documenting the National Couples' Health and Time StudyR03HD107126 · NICHD · UNIVERSITY OF MINNESOTA · PI KAMP DUSH, CLAIRE M · 2021 to 2022
$155k
NIA NIH HHS R01 AG096920NICHD NIH HHS P2C HD041023NICHD NIH HHS P2C HD050959NICHD NIH HHS P2C HD058484NICHD NIH HHS R01 HD094081NICHD NIH HHS R03 HD107126NICHD NIH HHS U01 HD108779NIMHD NIH HHS R21 MD018158
6 · The paper itself

Abstract

backgroundSexual minority individuals, including lesbian, gay, bisexual, and other non-heterosexual (LGB + ) adults have significantly greater risk for mental and physical health conditions, disparities linked with minority stress exposure.

methodsUtilizing a Biopsychosocial Minority Stress Framework, this study examined depressive symptoms, anxiety, and inflammatory markers [interleukin(IL)-6 and C-reactive protein (CRP)] in a diverse sample of 661 adults (388 heterosexual; 273 LGB + ).

resultsLGB + adults reported greater anxiety and depressive symptoms (ps < 0.01). This effect was partially mediated by greater exposure to adverse childhood experiences (ACES) among LGB + respondents. Compared to heterosexual adults, controlling for key potential confounds, LGB + adults exhibited greater elevations in CRP in relation to depressive symptoms (B

conclusionsLGB + adults may experience greater inflammatory burden due to both 1) greater prevalence of anxiety and depression, and 2) sensitization to negative inflammatory sequalae in the context of anxiety and depression. Greater ACES contributed to the greater prevalence of anxiety and depressive symptoms among LGB + as compared to heterosexual participants. Ultimately, differential prevalence of, and physiological responses, to anxiety and depressive symptoms may contribute to physical and mental health disparities among sexual minority adults.

Indexed as

AnxietyDepressionHealth Status DisparitiesHeterosexualityInflammationSexual and Gender MinoritiesAdultAdverse Childhood ExperiencesC-Reactive ProteinFemaleHumansInterleukin-6MaleMiddle AgedYoung AdultC-Reactive ProteinInterleukin-6AnxietyBisexualDepressionDepressive symptomsGayHeterosexualInflammationLesbianLGBTQ+Psychological well-beingSexually diverseSexual minorityStress

Identifiers

PMID41330456
PMCPMC13170463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.