ArticleCornea2026
Evaluation of Corneal Tomographic, Biomechanical and Pachymetric Characteristics in Patients With Keratoconus, Their First-Degree Relatives, and Normal Individuals.
Article in Cornea, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
Funding
Abstract
purposeThis study assessed corneal tomographic, biomechanical, and pachymetry using 3 multimodal imaging (MMI) diagnostic capabilitiesto detect keratoconus in first-degree relatives (FDR) of patients with keratoconus and normal populations.
methodsThis was a prospective cross-sectional study. A total of 118 eyes from 78 patients with keratoconus, 96 eyes from 54 FDR subjects, and 126 eyes from 63 healthy individuals were analyzed using the Oculus Pentacam HR, Oculus Corvis ST, and Cirrus OCTA 5000. Corneal tomography, biomechanics, and pachymetry were performed and compared between the 3 groups.
resultsNotable disparities in corneal tomography, biomechanics, and pachymetry were observed between FDR and healthy subjects. FDR exhibited a thinner cornea and reduced corneal biomechanical strength compared with normal eyes. In distinguishing keratoconus in FDR, the diagnostic capabilities of B.Ele.Th (back elevation at thinnest), BAD (Belin/Ambrósio Enhanced Ectasia Display), and TBI (tomographic biomechanics index) proved to be highly effective with area under the curve (AUC) beyond 0.90. Stepwise logistic regression (SLR) model combination of corneal tomography and biomechanics of IHD, CBI, and TBI showed an excellent accuracy of AUC:0.999 for detecting keratoconus in FDR than using single MMI alone.
conclusionsFDR with keratoconus indeed have an increased likelihood of developing corneal ectasia, including keratoconus itself. MMI screening of asymptomatic relatives can facilitate early stage or subclinical keratoconus detection.
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