Evidence map›Paper›PMID 41330368›Full record

ArticleCell host & microbe2025

Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota.

Rui Liu, Yue Zhang, Siyi Ge, Jennifer Y Cho, Nathaniel C Esteves, Jun Zhu, Ansel Hsiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rui LiuDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA.
Yue ZhangDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA.
Siyi GeDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA.
Jennifer Y ChoDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA; Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA.
Nathaniel C EstevesDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jun ZhuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ansel HsiaoDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: ansel.hsiao@ucr.edu.

Funding

Vibrio cholerae antinitrosative stress defenses and gut microbiome interactionR01AI157106 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HSIAO, ANSEL, ZHU, JUN · 2020 to 2024
$4.0M
The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infectionR01AI178908 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ansel Hsiao, Jun Zhu · 2023 to 2026
$3.2M
Defining the impact of interpersonal gut microbiota variation on oral cholera vaccine responsivenessR01AI181382 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Philip Patrick Ahern, Ansel Hsiao · 2024 to 2026
$2.3M
Small molecule signaling in regulation of gut microbiota structure and colonization resistanceR35GM158026 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2025 to 2025
$2.1M
Gut microbiome-mediated small-molecule signaling and resistance to invading microorganismsR35GM124724 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2017 to 2021
$1.8M
Phage mobilization and microbiota dynamics driving colonization resistance to Vibrio cholerae invasionR21AI181381 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DEGNAN, PATRICK H, HSIAO, ANSEL · 2024 to 2025
$393k
NIAID NIH HHS R01 AI157106NIAID NIH HHS R01 AI178908NIAID NIH HHS R01 AI181382NIAID NIH HHS R21 AI181381NIGMS NIH HHS R35 GM124724NIGMS NIH HHS R35 GM158026
6 · The paper itself

Abstract

The amount or type of dietary macronutrients dramatically changes the microbiota and physicochemical environment of the gut. Because the microbiota plays key roles in pathogen susceptibility, macronutrients could impact infection outcomes. We show that dietary protein sources differentially restrict colonization of Vibrio cholerae (V. cholerae) as well as impact pathogen-dependent changes in microbiota composition. Specifically, dietary proteins, notably casein, alter levels of the V. cholerae central flagellar regulator, FlrA, which controls expression of the type VI secretion system (T6SS), a key mediator of intra-bacterial competition. Resultant decreases in T6SS lead to a competitive disadvantage for V. cholerae against human commensal Escherichia coli, as well as changes in the abundance and composition of a model human gut microbiota. Mutations in FlrA restore V. cholerae T6SS expression and abrogate diet-dependent impacts on V. cholerae infection. These findings suggest dietary interventions for restricting V. cholerae and highlight the importance of diet in pathogen-commensal interactions.

Indexed as

DietDietary ProteinsGastrointestinal MicrobiomeVibrio choleraeAnimalsBacterial ProteinsCaseinsCholeraEscherichia coliGene Expression Regulation, BacterialHumansType VI Secretion SystemsBacterial ProteinsCaseinsDietary ProteinsType VI Secretion SystemsdietflrAmicrobiomeT6SSVibrio cholerae

Identifiers

PMID41330368
PMCPMC12834465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.