Evidence map›Paper›PMID 41330098›Full record

ArticleEnvironment international2025

Air pollution and breast cancer incidence in a United States-wide prospective cohort study: Examining sensitive periods of exposure.

Jennifer L Ish, Judy Y Ou, Alison M Rector-Houze, Nicole M Niehoff, Jianzhao Bi, Joel D Kaufman, Dale P Sandler, Alexandra J White

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer L IshEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.
Judy Y OuHuntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA; Social & Scientific Systems, Inc., a DLH Corporation Company, Durham, NC, USA.
Alison M Rector-HouzeHCA Healthcare Graduate Medical Education, Nashville, TN, USA.
Nicole M NiehoffReal-World Evidence & Health Outcomes Research Group, GSK Plc, Durham, NC, USA.
Jianzhao BiDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Joel D KaufmanDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA. Electronic address: alexandra.white@nih.gov.

Funding

Environment and Cancer EpidemiologyZIAES103332 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WHITE, ALEXANDRA · 2019 to 2025
$8.9M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Intramural NIH HHS Z01 ES044005Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIA ES103332
6 · The paper itself

Abstract

backgroundMounting evidence supports that air pollution is related to a higher breast cancer risk, yet the importance of exposure timing in this relationship remains unclear.

methodsIn the Sister Study, a United States-wide prospective cohort (n = 50,884, 2003-2009), we estimated time-varying annual concentrations of nitrogen dioxide (NO

resultsWe found limited evidence that air pollutant exposure during the time of a woman's first birth, most recent birth, or menopause transition was associated with heightened risk for breast cancer. When examining exposure flexibly over the long-term, a 10-ppb increase in NO

conclusionsWe identified unique periods of susceptibility to NO

Indexed as

Air PollutantsAir PollutionBreast NeoplasmsEnvironmental ExposureAdultAgedFemaleHumansIncidenceMiddle AgedNitrogen DioxideParticulate MatterProportional Hazards ModelsProspective StudiesUnited StatesAir PollutantsNitrogen DioxideParticulate MatterAir pollutionBreast cancerDistributed lag non-linear modelsWindows of susceptibility

Identifiers

PMID41330098
PMCPMC12874600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.