Evidence map›Paper›PMID 41330064›Full record

ReviewBiomedical materials (Bristol, England)2025

3D bioprinting of cell-laden constructs: technologies, bioink design, and biomedical applications.

Qinzhe Xing, Yufeng Liu, Jordan L Thomas, Wei Zhang, Muhammad Riaz, Michael Mak, Yibing Qyang

Abstract readReview
In one paragraph

Review in Biomedical materials (Bristol, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qinzhe XingDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, United States of America.ORCID 0000-0002-5774-2254
Yufeng LiuYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, United States of America.ORCID 0000-0001-9590-2805
Jordan L ThomasDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, United States of America.
Wei ZhangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, United States of America.ORCID 0000-0001-7693-9581
Muhammad RiazYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, United States of America.ORCID 0000-0002-0311-8392
Michael MakDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, United States of America.ORCID 0000-0001-6881-8130
Yibing QyangDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, United States of America.ORCID 0000-0002-0332-2449

Funding

Readily Available Stem Cell-Based Vascular Grafts for Emergent Surgical CareR01HL150352 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2020 to 2023
$2.8M
Human tissue-engineered blood vessels using induced pluripotent stem cellsR01HL116705 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2013 to 2017
$2.0M
Readily Available Biological Conduits to Treat Single Ventricle DefectsR01HL171984 · NHLBI · YALE UNIVERSITY · PI Yibing Qyang · 2024 to 2026
$1.7M
Development of HLA engineered universal vascular grafts from human iPSCsR01HL155411 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2021 to 2024
$1.7M
Modulation of heart function by Muscle LIM protein-mediated mechanotransductionR01HL164783 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2022 to 2025
$1.7M
NHLBI NIH HHS R01 HL116705NHLBI NIH HHS R01 HL150352NHLBI NIH HHS R01 HL155411NHLBI NIH HHS R01 HL164783NHLBI NIH HHS R01 HL171984
6 · The paper itself

Abstract

Three-dimensional (3D) cell printing is rapidly redefining how we engineer tissues by enabling the precise delivery of living cells within bio-inks to build complex, cell-laden structures. Unlike traditional approaches that seed cells onto inert scaffolds, this technique allows direct integration of cells into the construct, promoting enhanced cell infiltration, extracellular matrix (ECM) remodeling, and tissue-like functionality. Despite the explosion of interest, the field remains fragmented, with limited efforts to unify emerging data across platforms and applications. Our review addresses this gap by synthesizing recent advances in 3D cell printing in terms of key printing factors and parameters and adaptive bioprinting, presenting consensus and translative information such as printing parameters, identifying current established applications, and proposing future research directions based on the current

Indexed as

BioprintingPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsAnimalsBiocompatible MaterialsExtracellular MatrixHumansBiocompatible Materials3D bioprintingbioinkcell-containingorgan-on-chipsskin patchvascular graft

Identifiers

PMID41330064
PMCPMC13592461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.