Trial reportActa orthopaedica2025
Effect of patient specific instruments compared with conventional instruments in total knee arthroplasty : a randomized controlled trial.
Trial report in Acta orthopaedica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePatient-specific instrumentation (PSI) in total knee arthroplasty (TKA) aims to improve implant alignment and clinical outcomes, but its effectiveness remains uncertain. We aimed to compare whether PSI was superior to conventional instrumentation (CVI) in TKA. The primary outcome was the Oxford Knee Score (OKS) at 2 years with assessments of additional clinical outcomes up to 5 years after surgery.
methodsThis study included 70 knees with primary osteoarthritis randomized (1:1) to undergo TKA using either PSI or CVI. Outcomes were evaluated using patient-reported outcome measures (PROMs), radiographic alignment, and radiostereometric analysis (RSA) of migration over the full follow-up period of 5 years.
results68 knees underwent surgery as per protocol. At 2 years, 29 knees in the PSI group and 36 in the CVI group were assessed with the OKS, which improved significantly by 21.2 in the PSI group and 18.2 in the CVI group (mean difference [MD] 2.1; 95% confidence interval [CI] -1.5 to 5.7). PSI resulted in slightly increased tibial varus alignment (MD -1.4°; CI -2.3° to -0.4°), migrated slightly more into varus (mean difference at 2 years: -0.28 mm, CI -0.54 to -0.03 mm), and showed higher maximum total point motion (MTPM) during the period 1 to 2 years (mean difference: 0.13 mm; CI 0.01-0.25). At 5 years, 3 knees had been revised (PSI: 2; CVI: 1).
conclusionPSI did not demonstrate superior outcomes compared with CVI. These findings suggest that PSI may not provide significant benefits over conventional techniques in routine TKA.
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