Observational studyCritical care explorations2025
Long-Term Functional and Quality-of-Life Outcomes in Survivors of Refractory Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation.
Observational study in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
importanceLong-term functional outcomes and health-related quality of life (HRQoL) in survivors of cardiogenic shock treated with venoarterial extracorporeal membrane oxygenation (ECMO) remain poorly understood.
objectivesThis study aimed to evaluate these outcomes in a cohort of venoarterial ECMO survivors. DESIGN, SETTING, AND
participantsThis single-center observational study was conducted in the ICU of a French academic hospital and included consecutive adult patients treated with venoarterial ECMO who were discharged alive between February 2016 and December 2021. MAIN OUTCOMES AND MEASURES: The primary endpoint was a favorable functional outcome at least one year after ICU discharge, defined as a score on the modified Rankin Scale of 0 or 1, indicating no functional limitations affecting usual activities. Secondary endpoints included HRQoL, assessed using the EuroQol 5D five levels (EQ-5D-5L) and 36-item short-form health survey (SF-36) questionnaires. Of 79 hospital survivors, 65 patients were evaluated after a median follow-up of 2.8 years (1.2-4.2 yr). A favorable functional outcome was observed in 35 of 65 patients (54%). No association was found between ICU admission characteristics, serum neurobiomarkers (neuron-specific enolase, S100B), electroencephalogram findings during venoarterial ECMO, and functional outcome. Male sex was the only parameter associated with higher odds of favorable functional outcome (adjusted odds ratio, 4.19; 95% CI, 1.35-14.5). HRQoL assessments showed moderate-to-severe issues in 15% of patients, mainly affecting mobility, pain/discomfort, and mental health. Patients with favorable outcomes reported better scores across all domains of the EQ-5D-5L and higher scores on both the physical and mental components of the SF-36. CONCLUSIONS AND RELEVANCE: Approximately half of venoarterial ECMO survivors achieved excellent long-term functional outcomes. Nonetheless, a subset experienced ongoing limitations, particularly related to physical function and mental health, underscoring the need for targeted long-term follow-up and support.
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