Evidence map›Paper›PMID 41329733›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage.

Anthony Béguin, Marianne Chasseriaud, Guillaume Hollaender, Yves Jacob, Guillaume Mousseau, Thierry Heidmann, Odile Heidmann

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anthony BéguinUnité Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, CNRS UMR 9196, Gustave Roussy, Université Paris-Saclay, Villejuif 94805, France.ORCID 0009-0001-3539-6901
Marianne ChasseriaudUnité Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, CNRS UMR 9196, Gustave Roussy, Université Paris-Saclay, Villejuif 94805, France.
Guillaume HollaenderUnité Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, CNRS UMR 9196, Gustave Roussy, Université Paris-Saclay, Villejuif 94805, France.
Yves JacobUnité de Génétique Moléculaire des Virus à ARN, CNRS UMR 3569, Département Virologie, Institut Pasteur, Paris 75015, France.ORCID 0000-0001-9125-2374
Guillaume MousseauViroxis, Institut Gustave Roussy, Villejuif 94805, France.ORCID 0009-0007-4252-6894
Thierry HeidmannUnité Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, CNRS UMR 9196, Gustave Roussy, Université Paris-Saclay, Villejuif 94805, France.ORCID 0000-0002-9055-1687
Odile HeidmannUnité Physiologie et Pathologie Moléculaires des Rétrovirus Endogènes et Infectieux, CNRS UMR 9196, Gustave Roussy, Université Paris-Saclay, Villejuif 94805, France.ORCID 0000-0002-0496-2552

Funding

Agence Nationale de la Recherche (ANR) ANR-21-CE18-0028
6 · The paper itself

Abstract

Endogenous retroviruses (ERV) represent 8 to 10% of mammalian genome. While most ERV are defective, a few retroviral genes, such as the envelope syncytins, were exapted during evolution and likely contributed to the emergence of placental mammals. We have previously identified the oldest full-length retroviral envelope gene in the human genome,

Indexed as

Aspartic Acid EndopeptidasesEndogenous RetrovirusesGene Products, envViral Envelope ProteinsAnimalsEvolution, MolecularFemaleFurinHEK293 CellsHumansPregnancyPrimatesAspartic Acid EndopeptidasesFurinGene Products, envViral Envelope ProteinsBACE2ERVMER34-1/HEMOevolutionhuman endogenous retrovirus (HERV)interacting partner/receptor

Identifiers

PMID41329733
PMCPMC12704712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.