Evidence map›Paper›PMID 41329732›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Nitric oxide promotes rapid development of motility to accelerate biofilm dispersal in

Nathaniel C Esteves, Ran Tao, Qinqin Pu, Arkaprabha Banerjee, Arnold J T M Mathijssen, Jun Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Selective Trapping of Bacteria in Porous Media by Cell Length.Integrative and comparative biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathaniel C Esteves *Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ran Tao *Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104.
Qinqin PuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Arkaprabha BanerjeeDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Arnold J T M MathijssenDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-9577-8928
Jun ZhuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-9182-5224

Funding

Vibrio cholerae antinitrosative stress defenses and gut microbiome interactionR01AI157106 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HSIAO, ANSEL, ZHU, JUN · 2020 to 2024
$4.0M
The role of a bifunctional mucinase in modulating personalized gut microbiota-Vibrio cholerae interactions during infectionR01AI178908 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ansel Hsiao, Jun Zhu · 2023 to 2026
$3.2M
sRNA-regulated S-glutathionylation controls Vibrio cholerae virulenceR21AI175874 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZHU, JUN · 2023 to 2024
$457k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI157106HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI178908NIAID NIH HHS R01 AI157106NIAID NIH HHS R01 AI178908NIAID NIH HHS R21 AI175874
6 · The paper itself

Abstract

Bacterial biofilms are resilient multicellular communities that underlie persistent infections and environmental survival. Dispersal from biofilms is a pivotal event for transmission and pathogenesis, yet the host signals and bacterial mechanisms orchestrating this transition remain poorly understood. Here, we show that nitric oxide (NO), a ubiquitous host-derived signaling molecule, acts as a rapid trigger for biofilm dispersal in

Indexed as

BiofilmsNitric OxideVibrio choleraeCholeraCyclic GMPFlagellaFlagellinGene Expression Regulation, BacterialHumansbis(3',5')-cyclic diguanylic acidCyclic GMPFlagellinNitric Oxidebiofilmcyclic-di-GMPflagellar biosynthesisnitric oxideVibrio cholerae

Identifiers

PMID41329732
PMCPMC12704800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.