Evidence map›Paper›PMID 41329729›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Glycoside hydrolase-mediated glucomannan catabolism in

Cyrus Zhou, Matthew C Hibberd, Evan M Lee, Bo Pilgaard, Marlene Vuillemin, Emma Kiehn, Suzanne Henrissat, Marie A Crane, Jiye Cheng, Lara Pfaff and 10 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Applied and environmental microbiology · 2026
    Article
  3. Article
  4. Article
  5. Reply to Wang et al.: Linking microbial metabolites and gut epithelial responses to microbiome-directed therapeutic foods.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Reverse prediction of carbohydrate esterase polysaccharide targets.Biotechnology for biofuels and bioproducts · 2026
    Article
  7. Article
  8. Article
  9. Glycoside hydrolase-mediated glucomannan catabolism inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Cyrus Zhou *The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-4335-6894
Matthew C Hibberd *The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-6520-677X
Evan M LeeThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-4963-1359
Bo PilgaardDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.
Marlene VuilleminDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.
Emma KiehnDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.ORCID 0009-0006-8868-3046
Suzanne HenrissatThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.
Marie A CraneThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-5090-2163
Jiye ChengThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.
Lara PfaffDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.
Anne S MeyerDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.
Jesper HolckDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.ORCID 0000-0002-8072-1101
Nicolas TerraponArchitecture et Fonction des Macromolécules Biologiques, CNRS, Aix-Marseille Université, Marseille F-13288, France.ORCID 0000-0002-3693-6017
Juan J CastilloDepartment of Chemistry, University of California, Davis, CA 95616.
Garret CoutureDepartment of Chemistry, University of California, Davis, CA 95616.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA 95616.ORCID 0000-0001-7190-5323
Dmitry A RodionovInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Michael J BarrattThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.
Bernard HenrissatDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.
Jeffrey I GordonThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-8304-3548

Funding

INSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCET32HG000045 · NHGRI · WASHINGTON UNIVERSITY · PI MICHAEL R BRENT, Barak A Cohen · 1997 to 2026
$8.4M
REGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5M
REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINER37DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 1993 to 2015
$4.0M
Mechanism of action of a microbiota-directed complementary food that promotes ponderal growth in Bangladeshi children with moderate acute malnutritionF30DK131866 · NIDDK · WASHINGTON UNIVERSITY · PI ZHOU, CYRUS · 2022 to 2024
$138k
Identifying Prevotella copri-mediated effects of dietary glycan supplementation on microbial community and host metabolismF30DK142304 · NIDDK · WASHINGTON UNIVERSITY · PI Evan Matthew Lee · 2025 to 2026
$91k
Bill and Melinda Gates Foundation (GF) INV016367Gates Foundation INV-016367HHS | NIH (NIH) DK30292HHS | NIH (NIH) F30DK131866HHS | NIH (NIH) T32HG000045KU | Novo Nordisk Foundation Center for Protein Research, University of Copenhagen (CPR) NNF20SA0067193 NNF22OC0077058NHGRI NIH HHS T32 HG000045NIDDK NIH HHS F30 DK131866NIDDK NIH HHS F30 DK142304NIDDK NIH HHS R01 DK030292NIDDK NIH HHS R37 DK030292
6 · The paper itself

Abstract

Evidence is emerging that perturbed postnatal gut microbiota development is causally related to childhood undernutrition. Clinical trials in undernourished Bangladeshi children found that a polysaccharide-rich, microbiota-directed complementary food (MDCF-2) designed to repair this perturbation produced superior ponderal and linear growth compared to a standard ready-to-use supplementary food. Subsequent analyses disclosed several candidate bioactive polysaccharides in the MDCF and their bacterial targets, notably strains of

Indexed as

Gastrointestinal MicrobiomeGlycoside HydrolasesMalnutritionMannansAnimalsChildHumansMicePolysaccharidesPrebiotics(1-6)-alpha-glucomannanGlycoside HydrolasesMannansPolysaccharidesPrebioticscarbohydrate-active enzymesgut microbiome-directed therapeuticspolysaccharide utilization lociprebiotic discoverySegatella copri

Identifiers

PMID41329729
PMCPMC12704710

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.