ArticlePloS one2025
The relationship between sleep disorders and postoperative delirium in adult patients: Protocol for an updated systematic review and meta-analysis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostoperative delirium (POD) is a common complication after surgery. The association between sleep disorders and the risk of POD has been widely studied. Sleep disorders have emerged as a potential risk factor for POD, but recent studies provide conflicting evidence regarding the existence and the extent of the association. The aim of this systematic review and meta-analysis will be to estimate the association between sleep disorders and the risk of POD in adult patients. METHODS AND ANALYSIS: A systematic review will be conducted to estimate the association between sleep disorders and the risk of POD in adult patients. This systematic review protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement. Literature searches will be carried out in the PubMed, Embase, CINAHL, and PsycINFO databases from inception until August 2025 without language restrictions. Only observational studies that investigated the association between sleep disorders and POD will be included. Two independent reviewers will be responsible for the selection of studies, extraction of information and risk of bias assessment of the articles. A random effects model will be used to calculate the pooled risk estimates for the outcome. Subgroup analysis will be conducted to explore potential sources of heterogeneity. Publication bias will be estimated by funnel plots and Egger's test. Sensitivity analysis will also be performed to explore the stability of the overall effect size. Also, evidence quality will be assessed. All data will be analysed using Review Manager (V.5.3) and Stata (V.14.0) statistical software. DISCUSSION: The proposed systematic review and meta-analysis will highlight the association of sleep disorders and the risk of POD in adult patients. The findings of this review and meta-analysis will help clinicians consider the sleep disorders to make better health decisions. Trial registration: Prospero registration number: CRD42024604118.
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