Evidence map›Paper›PMID 41329624›Full record

ArticleActa haematologica2025

Hemophagocytic Syndromes in Adults: Real-World Data on Mortality from a Tertiary Reference Center.

Tatiana Wojtovicova, Drahomir Aujesky, Joerg C Schefold, Michael Daskalakis, Hansjakob Furrer, Urban Novak, Thomas Pabst, Britta Maurer, Burkhard Möller, Roman Christian Abegglen and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta haematologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tatiana WojtovicovaDepartment of Hematology and Central Hematology Laboratory, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland, wojtovicova.tatiana@gmail.com.
Drahomir AujeskyDepartment of General Internal Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Joerg C SchefoldDepartment of Intensive Care Medicine, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Michael DaskalakisDepartment of Hematology and Central Hematology Laboratory, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Hansjakob FurrerDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
Urban NovakDepartment of Oncology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Thomas PabstDepartment of Oncology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Britta MaurerDepartment of Rheumatology and Immunology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Burkhard MöllerDepartment of Rheumatology and Immunology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Roman Christian AbegglenIDSC Insel Data Science Center, University Hospital/Inselspital Bern, University of Bern, Bern, Switzerland.
Aristomenis ExadaktylosDepartment of Emergency Medicine, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
Annalisa BerzigottiDepartment for Visceral Medicine and Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Yara BanzInstitute of Pathology, University of Bern, Bern, Switzerland.
Ulrike BacherDepartment of Hematology and Central Hematology Laboratory, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Sacha S ZeerlederDepartment of Hematology, Luzerner Kantonsspital, Lucerne and University of Bern, Bern, Switzerland.
Nicolas BonadiesPractice for Hematology and Oncology, University of Bern, Bern, Switzerland.
André TichelliHematology, University Hospital of Basel, Basel, Switzerland.
Anne Angelillo-ScherrerDepartment of Hematology and Central Hematology Laboratory, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Alicia RovóDepartment of Hematology and Central Hematology Laboratory, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition characterized by excessive immune activation, cytokine storm, and aberrant macrophage function. Although HLH is well studied in children, data on adult HLH remain limited. Our primary goal was to examine in-hospital mortality and its associated risk factors in patients with HLH in a tertiary center.

methodsThis retrospective study at University Hospital Bern queried the hospital database using the i2b2 system to analyze adult HLH patients, assessing clinical, laboratory data, treatments, and outcomes according to the HLH-2004 criteria and Saint-Antoine score.

resultsFrom 845,846 patients seen in the hospital between 2014 and 2021, a cohort of 54 adult HLH patients was identified. The overall mortality rate was 40.7%. In univariate analysis, we found that deceased patients with HLH were significantly older than surviving patients (median age of 69.6 [range 22-83] vs. 52.5 [24-79] years old [p = 0.002]). Patients with HLH were significantly more likely to have cardiopulmonary and neurological complications, higher alkaline phosphatase levels, lower platelet counts, need platelet transfusions, and lower response rate to the HLH therapy. In multivariate analysis, age (HR 0.94; 95% CI 0.89-0.99; p = 0.024), cardiopulmonary (HR 7.045; 95% CI 1.28-38.66, p = 0.025), neurologic complications (HR 5.55; 95% CI 1.01-30.51; p = 0.04), and the requirement of platelet transfusions (HR 6.22; 95% CI 1.16-33.20; p = 0.032) were all independently associated with in-hospital mortality.

conclusionsThis study identifies risk factors whose early presence can be used to stratify management strategies and improve prognosis in patients with HLH.

Indexed as

AdultsHemophagocytic lymphohistiocytosisHemophagocytic syndromeSt. Antoine score

Identifiers

PMID41329624
PMCPMC12795530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.