Evidence map›Paper›PMID 41329554›Full record

ArticleACS infectious diseases2025

Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in

Wenyin Su, William Nguyen, Ghizal Siddiqui, Jerzy M Dziekan, Danushka Marapana, Jocelyn Sietsma Penington, Somya Mehra, Zahra Razook, Kirsty McCann, Anna Ngo and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wenyin SuThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
William NguyenThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.ORCID 0000-0002-3984-2390
Ghizal SiddiquiMonash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia.ORCID 0000-0002-3153-3198
Jerzy M DziekanThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Danushka MarapanaThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Jocelyn Sietsma PeningtonThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.ORCID 0000-0003-1561-0074
Somya MehraThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Zahra RazookInstitute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, Geelong, Victoria 3220, Australia.
Kirsty McCannInstitute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, Geelong, Victoria 3220, Australia.
Anna NgoThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Kate E JarmanThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Alyssa E BarryInstitute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, Geelong, Victoria 3220, Australia.
Anthony T PapenfussThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Paul R GilsonBurnet Institute, Melbourne 3004, Australia.ORCID 0000-0001-8778-6795
Darren John CreekMonash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia.ORCID 0000-0001-7497-7082
Alan F CowmanThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Brad E SleebsThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.ORCID 0000-0001-9117-1048
Madeline G DansThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.ORCID 0000-0001-9386-0648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmepsin V (PMV), an essential aspartyl protease, plays a critical role during the asexual blood stage of infection of

Indexed as

AntimalarialsAspartic Acid EndopeptidasesPeptidomimeticsPlasmodium falciparumProtozoan ProteinsHumansMalaria, FalciparumAntimalarialsAspartic Acid EndopeptidasesPeptidomimeticsplasmepsinProtozoan Proteinsantimalarialaspartyl proteasemalariaplasmepsinPlasmodium

Identifiers

PMID41329554
PMCPMC12706786

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.