ArticleEuropean geriatric medicine2026
The effect of early postoperative acute pain on postoperative delirium in older persons undergoing abdominal surgery: a secondary analysis of multicenter prospective data.
Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06964893 (The Effect of Early Postoperative Pain on Postoperative Delirium), which is not on this map. Cited by 1 paper.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Early Postoperative Pain on Postoperative Delirium (POD) in Elderly Patients Undergoing Abdominal Surgery:a Secondary Analysis of Multicenter Prospective Data
Who cites it
1 citing paper in PubMed.
- Effects of liposomal bupivacaine versus ropivacaine for fascia iliaca compartment block on postoperative pain and delirium in elderly patients undergoing hip arthroplasty.American journal of translational research · 2026Article
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10 authors.
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Abstract
purposeOlder persons frequently experience postoperative acute pain and delirium, however, there is little clinical data on their possible interrelationships.
methodsA secondary analysis of multicenter prospective data, including tertiary hospitals in Five Chinese Regions, from April 2020 to April 2022. Older persons (≥ 65 years) scheduled for elective abdominal surgery under general anesthesia, without auditory, visual, or cognitive impairments, who completed assessments for postoperative delirium, anxiety, and depression. The impact of early postoperative acute pain on postoperative delirium in older persons undergoing abdominal surgery was evaluated using univariate and multivariate logistic regression, propensity score matching, and subgroup analysis.
resultsThe study cohort included 2,674 patients. The median age was 70 years, and 66.5% of the patients were male. Delirium occurred in 13.2% (n = 354) of patients in postoperative 7 days (POD 7), with a significantly higher prevalence in the moderate-to-severe pain group (unadjusted: 16.3 vs. 9.6%, p < 0.001). Moderate-to-severe pain on POD1 showed a significant association with delirium occurrence in POD 7 according to univariate logistic regression (OR 1.83, 95% CI 1.445-2.319, p < 0.001), multivariable logistic regression (OR 1.63, 95% CI 1.274-2.084, p < 0.001), and propensity score matching (PSM) model (OR 1.44, 95% CI 1.108-1.879, p = 0.006).
conclusionIn older persons undergoing elective abdominal surgery, moderate-to-severe pain on POD 1 was significantly associated with both delirium and depressive symptoms within 7 days of surgery. Improved early postoperative analgesic strategies may aid in preventing delirium.
trial registrationClinicalTrials.gov identifier: NCT06964893 (2025-05-07).
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