Evidence map›Paper›PMID 41329422›Full record

ArticleJournal of autism and developmental disorders2025

Clinical Features of Children at Risk of Profound Autism.

M A Hodge, K A Boulton, R Sutherland, S Baracz, N Ong, B Bennett, G Brooks, A J Guastella, N Silove

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M A HodgeChild Development Unit, The Children's Hospital at Westmead, Corner Hawkesbury Road, Hainsworth St., Westmead, NSW, 2145, Australia. antoinette.hodge@health.nsw.gov.au.ORCID http://orcid.org/0000-0003-4101-9616
K A BoultonChild Neurodevelopment and Mental Health Team, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia.
R SutherlandSydney School of Health Sciences, The University of Sydney, Susan Wakil Health Building, Western Avenue, Camperdown, NSW, 2050, Australia.
S BaraczParramatta Early Childhood Assessment Team, The Children's Hospital at Westmead - Auburn Community Health Centre, Auburn, NSW, 2144, Australia.
N OngChild Development Unit, The Children's Hospital at Westmead, Corner Hawkesbury Road, Hainsworth St., Westmead, NSW, 2145, Australia.
B BennettChild Development Unit, The Children's Hospital at Westmead, Corner Hawkesbury Road, Hainsworth St., Westmead, NSW, 2145, Australia.
G BrooksParramatta Early Childhood Assessment Team, The Children's Hospital at Westmead - Auburn Community Health Centre, Auburn, NSW, 2144, Australia.
A J GuastellaChild Neurodevelopment and Mental Health Team, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia.
N SiloveChild Development Unit, The Children's Hospital at Westmead, Corner Hawkesbury Road, Hainsworth St., Westmead, NSW, 2145, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe concept of profound autism was coined in 2021 to better describe and understand the needs of autistic people with low cognitive and adaptive functioning skills and limited verbal communication. We sought to examine the clinical and demographic features of children referred to a multidisciplinary diagnosis and assessment clinic who were at risk of profound autism and those that did meet the definition of profound autism.

methodsParticipants were 513 autistic children aged 1-16 years seen in a large diagnosis and assessment clinic for a multidisciplinary assessment of social, communication, adaptive, cognitive/developmental skills and behaviour.

resultsA quarter of children presenting to the assessment service with autism also met the 'at risk' profound criteria. These children were of younger age (Age = 1.79 years) at first concern and at diagnosis (Age = 3.93 years) than children in the not profound group. They also had more concerns pertaining to elopement (escape from the caregiver's care).

conclusionThese findings add to our understanding of the characteristics of children who are at risk of profound autism. These findings have implications for clinical practice, including informing assessment processes, need for longitudinal follow up assessment, support planning and helping diagnosticians determine the appropriate level of support needed. Furthermore, these findings support calls for consideration of this group in policy planning, funding and earlier service access and ongoing follow up.

Indexed as

AutismChild and adolescentDevelopmentProfound autism

Identifiers

PMID41329422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.