Evidence map›Paper›PMID 41329395›Full record

ArticleInsights into imaging2025

Localization of obstruction sites in obstructive azoospermia: role of combined transscrotal-transrectal ultrasonography.

Xin Li, Chen-Cheng Yao, Chen-Wang Zhang, Xiao-Bo Wang, Li-Ren Jiang, Zheng Li, Peng Li, Rong Wu

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Article in Insights into imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Xin Li *Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen-Cheng Yao *Department of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen-Wang ZhangDepartment of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiao-Bo WangDepartment of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li-Ren JiangDepartment of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zheng LiDepartment of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peng LiDepartment of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lipengyxy@sjtu.edu.cn.
Rong WuDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wurong7111@163.com.ORCID http://orcid.org/0000-0003-3528-5360

Funding

the National Key Research and Development Program of China 2022YFC2702700the National Key Research and Development Projects 2022YFC3602400the National Natural Science Foundation of China 82071931, 82130057the program from Science and Technology Commission of Shanghai Municipality 20Y11912400
6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic performance of combined transscrotal-transrectal ultrasonography in predicting sites of obstructive azoospermia. MATERIALS AND

methodsFrom June 2019 to March 2023, 166 obstructive azoospermia patients who underwent surgical exploration were enrolled in the retrospective study. The data of combined transscrotal-transrectal ultrasonography in 166 patients were collected and analyzed. The receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic performance of these ultrasonographic measurements for localizing different obstructive sites.

resultsThere were 9 sides of intratesticular obstruction, 239 sides of epididymal obstruction, 68 sides of vas deferens obstruction, and 16 sides of ejaculatory duct obstruction. The sensitivity, specificity, and the area under the curve (AUC) for combined transscrotal-transrectal ultrasonography were 44.4%, 98.5% and 0.714 for diagnosing intratesticular obstruction; 97.9%, 84.9% and 0.919 for diagnosing epididymal obstruction; 82.4%, 99.2% and 0.913 for diagnosing vas deferens obstruction; and 87.5%, 99.1% and 0.93 for diagnosing ejaculatory duct obstruction. The sensitivity, specificity, and AUC were 88.9%, 83.9% and 0.842 in diagnosing intratesticular obstruction for a rete testis thickness cut-off of 3.0 mm; 81.0%, 100% and 0.949 in diagnosing vas deferens obstruction for a 0.8 mm cutoff for the internal diameter of the scrotal section of the vas deferens; and 62.5%, 92.6% and 0.769 in diagnosing ejaculatory duct obstruction for a seminal vesicle diameter cut-off of 12.5 mm.

conclusionCombined transscrotal-transrectal ultrasonography, evaluating specific structures of rete testis thickness, seminal vesicle diameter, and the internal diameter of the scrotal vas deferens, could accurately localize obstruction sites in obstructive azoospermia patients. CRITICAL RELEVANCE STATEMENT: Combined transscrotal-transrectal ultrasonography demonstrated high diagnostic performance in predicting the sites of epididymal, vas deferens, and ejaculatory duct obstruction in patients with obstructive azoospermia. KEY POINTS: The diagnostic performance of combined transscrotal-transrectal ultrasonography in obstructive azoospermia was evaluated. Ultrasound measurements of specific structures significantly improve the prediction of obstruction sites. Combined transscrotal-transrectal ultrasonography accurately localizes obstruction sites in obstructive azoospermia patients.

Indexed as

Obstructive azoospermiaObstructive siteTransscrotal–transrectal ultrasonography

Identifiers

PMID41329395
PMCPMC12672963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.