ArticleDiscover oncology2025
Impact of surgery on survival in TNBC with bone metastases only: a propensity score-matched SEER database analysis.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundBreast cancer is the most common malignancy among women, with triple-negative breast cancer associated with the poorest prognosis, often metastasizing to the bones. There is still controversy over whether surgical resection of the primary site can provide survival benefits in patients with TNBC bone metastases only. We conducted a retrospective analysis of this issue using the SEER database.
methods435 TNBC patients with bone metastasis at the time of diagnosis were extracted from the population-based Surveillance, Epidemiology, and End Results database (SEER). The bias between surgery and non-surgery group was minimized with Propensity Score Matching (PSM).
resultsThere were 126 patients in each group after PSM. Univariate and multivariate analysis showed that histology type, chemotherapy and surgery were significant prognostic indicators. Stepwise regression analysis also yielded the same results. Compared with the non-surgery group, primary site surgery group has longer OS and CSS. Subgroup analysis shows that expanding the surgical scope does not have significant prognostic benefits for both OS and CSS. Further analysis showed that surgery plus systemic treatment is a better option than only surgery.
conclusionIn TNBC patients with bone metastases only, compared to the non-surgery group, the primary site surgery group shows longer OS and CSS. Surgery combined with systemic treatment is a preferable treatment option.
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