Observational studyInternational journal of colorectal disease2025
Perianal fistulas: a new management approach using mesenchymal stem cells as a human, biological and autologous tool-a single-centre observational study.
Observational study in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe surgical treatment of perianal fistulas is challenging, especially in complex cases. Many surgical options may cause impairment of the anal sphincter with subsequent incontinence or may be less effective with a high number of relapses or the persistence of the pathology. New techniques, such as the use of mesenchymal stem cells, are becoming increasingly important because of their effectiveness and lower risk of complications.
methodsIn this single-centre prospective observational study, patients with complex perianal fistulas were treated via the infiltration of mesenchymal stem cells that had been purified using the Lipogems® system.
resultsThis study included 63 patients with complex perianal fistulas who were treated with mesenchymal stem cells extracted from adipose tissue. Successful clinical healing was observed in 43 (68.25%) patients. Eleven (17.4%) patients presented recurrence after treatment, and 9 (14.3%) had persistent incomplete healing. Minor postoperative complications were observed in six (9.5%) patients, which were related to adipose tissue harvesting in three patients. In the majority of patients, postoperative pain was mild or not present.
conclusionsMesenchymal stem cells offer an innovative therapeutic tool for treating perianal fistulas. This study confirms their safety and efficacy in treating complex perianal fistulas. Nevertheless, more extensive patient follow-up is necessary, as demonstrated by the most recent literature on related techniques.
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