Evidence map›Paper›PMID 41329282›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Synaptic Vesicle Exocytosis and Endocytosis in Motor Nerve Endings of Transgenic Mice Modeling Amyotrophic Lateral Sclerosis upon Antioxidant Treatment and Gene-Cell Therapy.

P N Grigoryev, A L Zefirov, R D Mukhamedzyanov, I I Salafutdinov, R R Islamov, M A Mukhamedyarov

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

P N GrigoryevKazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
A L ZefirovKazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
R D MukhamedzyanovKazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
I I SalafutdinovKazan (Volga) Federal University, Kazan, Russia.
R R IslamovKazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia.
M A MukhamedyarovKazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia. marat.muhamedyarov@kazangmu.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exocytosis and endocytosis of synaptic vesicles were studied in experiments with motor nerve endings of diaphragm neuromuscular preparations isolated from transgenic mice with a model of amyotrophic lateral sclerosis (ALS); treatment simulated antioxidant (edaravone) and gene-cell (umbilical cord blood mononuclear cells (UCB-MNCs) producing VEGF, GDNF, and NCAM) therapies. None of the treatments was found to significantly change the FM 1-43 fluorescent dye loading due to synaptic vesicle endocytosis. Gene-cell therapy increased the rate of dye unloading due to synaptic vesicle exocytosis, while antioxidant therapy did not change the FM 1-43 unloading rate. Based on the findings, gene-cell therapy was assumed to facilitate synaptic vesicle transport to release sites upon high-frequency stimulation in motor nerve endings of transgenic mice.

Indexed as

Amyotrophic Lateral SclerosisAntioxidantsEndocytosisExocytosisGenetic TherapyMotor NeuronsSynaptic VesiclesAnimalsDisease Models, AnimalHumansMiceMice, TransgenicAntioxidantsamyotrophic lateral sclerosisantioxidant therapyexocytosis and endocytosis of synaptic vesiclesgene-cell therapyneuromuscular junctiontransgenic mice

Identifiers

PMID41329282

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.